Baohuoside I宝藿苷 I,113558-15-9

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Baohuoside I

CAS No. : 113558-15-9

MCE 国际站：Baohuoside I

产品活性：Baohuoside I 是从朝鲜淫羊藿中得到的黄酮类化合物，作为 CXCR4 的抑制剂，能够抑制 CXCR4 的表达，诱导凋亡，具有抗肿瘤活性。

研究领域：GPCR/G Protein  |  Immunology/Inflammation  |  Apoptosis

作用靶点：CXCR  |  Apoptosis

In Vitro: Baohuoside I is an inhibitor of CXCR4, and downregulates CXCR4 expression at 12-25 μM. Baohuoside I (0-25 μM) suppresses NF-κB activation in a dose-dependent manner, suppresses CXCL12 induced the invasion of cervical cancer cells. Baohuoside I also inhibits invasion of breast cancer cells. Baohuoside I inhibits A549 cell viability, with IC₅₀s of 25.1 μM at 24 h, 11.5 μM and 9.6 μM at 48 h and 72 h, respectively. Baohuoside I ((25 μM) suppresses the caspase cascade in A549 cells, elevates ROS levels and activates JNK and p38^MAPK signaling cascade. Baohuoside I (3.125, 6.25, 12.5, 25.0 and 50.0 µg/mL) significantly and dose-dependently blocks the growth of esophageal squamous cell carcinoma Eca109 cells, with an IC₅₀ of 4.8 µg/mL at 48 h.

In Vivo: Baohuoside I (25 mg/kg) decreases β-catenin protein levels, cyclin D1 and survivin expression in nude mice.

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