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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
SK-0403
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1265.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥1150.0 |
| 规格： | 10 mg | 产品价格： | ￥1700.0 |
| 规格： | 50 mg | 产品价格： | ￥4250.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Anagliptin
CAS No. : 739366-20-2
MCE 国际站：Anagliptin
产品活性：Anagliptin (SK-0403) 是一种高选择性的、有效的、具有口服活性的二肽酰肽酶 4 (DPP-4) 抑制剂，IC50 值为 3.8 nM，对 DPP-8 和 DDP-9 的选择性相对较弱，IC50 值分别为 68 nM 和 60 nM。
研究领域：Metabolic Enzyme/Protease
作用靶点：Dipeptidyl Peptidase
In Vitro: Anagliptin (SK-0403) (0-100 μM; 24 h) attenuates s-DPP-4-induced smooth muscle cells proliferation.
Anagliptin (100 μM; 10 min) reduces TNF-α production in cultured monocytes.
Anagliptin (0.001-10 μM; 24 h) significantly suppresses sterol regulatory element‐binding protein activity in HepG2 cells (21% decrease).
In Vivo: Anagliptin (SK-0403) (0.3%; in diet; 16 weeks) reduces atherosclerotic lesion and does not increase the number of circulating EPCs in apoliporotein E (apoE)-deficient mice.
Anagliptin (0.3%; in diet; 4 weeks) exhibits a lipid‐lowering effect in a hyperlipidemic mice model.
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