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10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥563.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥512.0 |
| 规格： | 10 mg | 产品价格： | ￥818.0 |
| 规格： | 50 mg | 产品价格： | ￥2450.0 |
| 规格： | 100 mg | 产品价格： | ￥4000.0 |
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GANT 58
CAS No. : 64048-12-0
MCE 国际站：GANT 58
产品活性：GANT 58 (NSC 75503) 是一种有效的 GLI 拮抗剂，抑制 GLI1 诱导的转录，IC50 为 5 μM。
研究领域：Stem Cell/Wnt
作用靶点：Gli
In Vitro: GANT58 is a downstream inhibitor of Hh signaling. GANT58 is an indeed inhibitor of Hh signaling downstream of Smo and Sufu. GANT58 mainly acts at the nuclear level because transcription induced by GLI1 with a mutated nuclear export signal is still blocked. GANT58 efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth using human prostate cancer cells harboring downstream activation of the Hh pathway.
GANT58 (NSC75503) has been shown to inhibit transcriptional activation by GLI1 (as well as by the other GLI species). GANT58 has been shown to inhibit GLI transactivation.
In Vivo: Nude mice are injected s.c. with GLI1-positive 22Rv1 prostate cancer cells, and tumors are established (median size ≈250 mm3). Nude mice are treated with daily s.c. injections at a concentration of 50 mg/kg of cyclopamine, GANT61, GANT58, or solvent only (n=4-5 for each group). However, after 3 days, cyclopamine-treated animals presented with severe ulcerations at the injection sites. Therefore, changing the treatment regimen to injections only every second day. To be able to compare all compounds, this protocol is also introduced for the GANTs, although mice treated with these compounds showed no such signs of toxicity. All injections are done 2-3 cm away from the tumors. During an 18-day treatment period, suppression of tumor cell growth is observed for all compounds. Treatment with cyclopamine or GANT58 results in the inhibition of additional xenograft growth and limited the increase in tumor size.
相关产品：Bioactive Compound Library Plus | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Transcription Factor-Targeted Library | Targeted Diversity Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | GANT 61 | Glabrescione B | GLI antagonist-1 | TPB15
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文献和实验3.58 3.41 3.29 3.20 3.12 3.06 2.96 2.86 2.76 2.64 2.52 2.39 15 16 4.69 4.08 3.73 3.50 3.34 3.22 3.12 3.05 2.99 2.89 2.79 2.68 2.57 2.45 2.32 16 17 4.62 4.01 3.66 3.44 3.28 3.16 3.06 2.98 2.92 2.82 2.72 2.62 2.50 2.38 2.25 17 18 4.56 3.95
（7） 1 30 46 16 -2 1 2 38 50 12 -4 3 3 48 52 4 4 3 4 48 52 4 4 3 5 60 58 -2 -8 6 6 46 64 18 8 6 7 26 56 30 8 6 8 58 54 -4 10 8 9 46 54 8 12 9 10 48 58 10 16 10 11 44 36 -8 18 11 12 46 54 8 30 12 68 R=10 将表中10.1中
安装步骤：1. 右击软件压缩包，选择解压到 SPSS 24 64 位安装包。2. 双击打开 SPSS_Statistics_24_win64。3. 等待安装。4. 点击下一步。5. 点击选择 「我接受许可协议中的全部条款」，然后点击下一步。6. 点击下一步7. 点击选择我接受，然后点击下一步。8. 点击更改可以自行选择安装路径，这里我安装到 D 盘，所以直接把字母 C 更改为 D 即可，然后点击下一步。9. 点击安装。10. 等待安装完成（大概需要 6 分钟）。11. 点击完成。12. 点击
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