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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
372196-77-5
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥563.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥320.0 |
| 规格： | 10 mg | 产品价格： | ￥512.0 |
| 规格： | 25 mg | 产品价格： | ￥1152.0 |
| 规格： | 50 mg | 产品价格： | ￥1958.0 |
| 规格： | 100 mg | 产品价格： | ￥2727.0 |
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PIK-75 hydrochloride
CAS No. : 372196-77-5
MCE 国际站：PIK-75 hydrochloride
产品活性：PIK-75 hydrochloride 是一种可逆的 DNA-PK 和 p110α-选择性的抑制剂，抑制 DNA-PK，p110α 和 p110γ，IC50 分别为 2，5.8 和 76 nM。PIK-75 hydrochloride 抑制 p110α 效果比抑制 p110β (IC50=1.3 μM) 高 200 多倍。PIK-75 hydrochloride 诱导凋亡 (apoptosis)。
研究领域：Cell Cycle/DNA Damage | PI3K/Akt/mTOR | Apoptosis
作用靶点：DNA-PK | PI3K | Apoptosis
In Vitro: PIK-75 also inhibits p110δ, PI3KC2β, mTORC1, ATM, hsVPS34, PI3KC2α, mTORC2, ATR and PI4KIIIβ with IC50s of 510 nM, ~1 μM, ~1 μM, 2.3 μM, 2.6 μM, ~10 μM, ~10 μM, 21 μM, ~50 μM, respectively.
PIK-75 alone blocks Thr 308 phosphorylation in L6 myotubes and 3T3-L1 adipocytes with IC50 values of 1.2 and 1.3 μM, respectively.
PIK-75 (1-1000 nM; 5 min) blocks the phosphorylation of PKB induced by insulin on both Ser473and Thr308 in CHO-IR cells in a dose-dependent manner, with an IC50 of 78 nM.
PIK-75 (0.1-1000 nM; 48 hours) inhibits the proliferation and survival of pancreatic cancer cells through apoptotic cell death.
PIK-75 (0.1-1000 nM) also reduces the colony formation of pancreatic cancer MIA PaCa-2 and AsPC-1 cells.
In Vivo: PIK-75 (2 mg/kg) potentiates anticancer activity of Gemcitabine (20 mg/kg) in vivo. Gemcitabine (20 mg/kg) or PIK-75 (2 mg/kg) alone reduces the tumor growth to similar degree. Beneficial effect of PIK-75/Gemcitabine is evident as this combination markedly reduces the tumor growth in vivowithout affecting the body weights of mice.
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文献和实验3.63 3.24 3.01 2.85 2.74 2.66 2.59 2.42 2.24 2.01 8.53 6.23 5.29 4.77 4.44 4.20 4.03 3.89 3.55 3.18 2.75 18 4.41 3.55 3.16 2.93 2.77 2.66 2.58 2.51 2.34 2.15 1.92 8.29 6.01 5.09 4.58 4.25 4.01 3.84 3.71 3.37 3.00 2.57 20 4.35 3.49 3.10 2.87 2.71
【分享】MIRNA(microRNA)检测实验流程(加polyA法) (2011
-miR-124 73 3 hsmq-0033_01 MIMAT0000443 hsa-miR-125a-5p 77 4 hsmq-0034_01 MIMAT0000423 hsa-miR-125b 75 5 hsmq-0035_01 MIMAT0000429 hsa-miR-137 76 6 hsmq-0036_01 MIMAT0000250 hsa-miR-139-5p 75 7 hsmq-0037_01 MIMAT0000437
MIRNA(microRNA)检测实验流程(加polyA法)
MIMAT0000443 hsa-miR-125a-5p 77 4 hsmq-0034_01 MIMAT0000423 hsa-miR-125b 75 5 hsmq-0035_01 MIMAT0000429 hsa-miR-137
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