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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 英文名：
DMTU
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
534-13-4
- 规格：
10 mM * 1 mL/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥500.0 |
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N,N'-Dimethylthiourea
CAS No. : 534-13-4
MCE 国际站：N,N'-Dimethylthiourea
产品活性：N,N'-Dimethylthiourea (DMTU) 是从黑蒜中分离出来的，是口服有效的羟基自由基 (•OH) 的清除剂，通过活化的中性粒细胞在体外阻止 •OH 的产生。N,N'-Dimethylthiourea 通过发挥抗氧化作用，包括 •OH 清除和抗炎作用，防止水浸限制应激 (WIRS) 诱导的大鼠胃粘膜损伤。
研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
In Vivo: N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks.
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