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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
OPC12759; Proamipide
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
90098-04-7
- 规格：
10 mM * 1 mL/500 mg/1 g/5 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥400.0 |
| 规格： | 1 g | 产品价格： | ￥500.0 |
| 规格： | 5 g | 产品价格： | ￥1620.0 |
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Rebamipide
CAS No. : 90098-04-7
MCE 国际站：Rebamipide
产品活性：Rebamipide (OPC12759) 是一种口服有效的胃保护剂。Rebamipide 通过诱导 COX-2 的表达来增强内源性 PGs 的产生 (特别是胃内 PGE2)，从而保护胃粘膜免受伤害。Rebamipide 还具有抗胃癌细胞增殖活性。Rebamipide 可用于粘膜保护、胃十二指肠溃疡，胃炎和胃癌的研究。
作用靶点：COX
In Vitro: Rebamipide (1.4, 2.7, 5.4 mM; 24 h) inhibits proliferation of gastric cancer cell.
?Rebamipide (5.4 mM; 30 min) activates Smad signaling pathway in AGS cells.
?Rebamipide (5.4 mM; 3 h) induces the expression of Cdk inhibitor p21 in AGS cells.
In Vivo: Rebamipide (5, 15, 50 mg/kg; p.o.; once daily for 14 days) enhances the expression of COX-2 and PGE2, and protects gastric mucosa from acid-induced injury in rat gastric mucosa.
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