Busulfan白消安,55-98-1

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Busulfan

CAS No. : 55-98-1

MCE 国际站：Busulfan

产品活性：Busulfan 是一种有效的烷化抗肿瘤剂，通过交联 DNA 以及 DNA 和蛋白质造成 DNA 损伤。Busulfan 抑制硫氧还蛋白还原酶，也可以诱导细胞凋亡。Busulfan 是一种免疫抑制和清髓性化疗活性分子。

研究领域：Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：DNA Alkylator/Crosslinker  |  Apoptosis

In Vitro: Busulfan (120 μM; 24 h) incited a moderate p53 activation, but strong Erk, p38, and JNK phosphorylation, in a time-dependent manner.
Busulfan (120 μM; 24 h) results in premature senescence in WI38 cells via the Erk and p38 MAPK pathway, reduces GSH and increases ROS production, but the production can be suppressed by NADPH oxidase.

In Vivo: Busulfan can be used in animal modeling to establish models of acute aplastic anemia.

Busulfan (40 mg/kg; i.p; single dose) increases apoptosis and decreases the testis weight in mice.
Busulfan (2.5, 5.0 mg/kg, i.p.) causes earlier occurrence of persistent esturs in a dose dependent manner in rats. Busulfan (5.0 mg/kg) also increases the incidence of uterine adenocarcinomas and multiplicity of uterine neoplastic lesions

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