Melatonin褪黑素,73-31-4

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Melatonin

CAS No. : 73-31-4

MCE 国际站：Melatonin

产品活性：Melatonin 是一种由松果体分泌的激素，可激活褪黑激素受体。Melatonin 在睡眠中起作用并具有重要的抗氧化和抗炎特性。Melatonin 是一种新型的选择性 ATF-6 抑制剂，可通过 COX-2 下调诱导人肝癌细胞凋亡。Melatonin 通过内质网应激减弱palmitic acid-induced (HY-N0830)诱导的小鼠颗粒细胞凋亡。

研究领域：GPCR/G Protein | Neuronal Signaling | Autophagy | Metabolic Enzyme/Protease | Apoptosis

作用靶点：Melatonin Receptor | Autophagy | Mitophagy | Endogenous Metabolite | Apoptosis

结构分类：其他类

In Vivo: Melatonin increases the levels of activated PTEN, RSK-1, mTOR and AMPKα kinases, mildly inhibits ERK-1/2 phosphorylation and Bad phosphorylation, significantly inhibits phosphorylations of S6 Ribosomal Protein, 4E-BP1, GSK-3α and GSK-3β, and slightly increases PRAS40 phosphorylation in animals. Melatonin ameliorates the neurotoxiciy and astrocyte activation induced by Aβ_1-42 in the cerebral cortex. Melatonin also blocks the reduction in Reelin and Dab1 expression induced by Aβ_1-42. Melatonin treatment and lack of NLRP3^-/- share similar inhibition of NF-κB and NLRP3 signaling pathway in mice. Melatonin treatment and lack of NLRP3^-/- share some patterns of clock genes expression, and improve cardiomyocytes morphology in mice.

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