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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CP-456773; CRID3
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
210826-40-7
- 规格：
500 μg/1 mg
| 规格： | 500 μg | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥750.0 |
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MCC950
CAS No. : 210826-40-7
MCE 国际站：MCC950
产品活性：MCC950 (CP-456773; CRID3) 是一种有效，选择性的 NLRP3 抑制剂，在BMDMs 和 HMDMs中的IC50 分别为 7.5 nM 和 8.1 nM。
作用靶点：NOD-like Receptor (NLR)
In Vitro: MCC950 blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. The effect of MCC950 on NLRP3 inflammasome activation is tested in mouse bone marrow derived macrophages (BMDM) and human monocyte derived macrophages (HMDM). The IC50 of MCC950 in BMDM is approximately 7.5 nM, while in HMDM it has a similar inhibitory capacity (IC50=8.1 nM). MCC950 also dose dependently inhibit IL-1β but not TNF-α secretion.MCC950 specifically blocks caspase-11-directed NLRP3 activation and IL-1β secretion upon stimulation of the non-canonical pathway. NLRC4-stimulated IL-1β and TNF-α secretion (as activated by Salmonella typhimurium) are not inhibited by MCC950 even at a concentration of 10 µM. MCC950 does not inhibit caspase-1 activation or IL-1β processing in response to S. typhimurium. The expression of pro-caspase-1 and pro-IL-1β in cell lysates is not substantially affected by MCC950 treatment.
In Vivo: MCC950 reduces Interleukin-1p (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Pre-treatment with MCC950 reduces serum concentrations of IL-1β and IL-6 while it does not considerably decrease the amount of TNF-α. Treatment of mice with MCC950 delays the onset and reduced the severity of EAE. Intracellular cytokine staining and FACS analysis of brain mononuclear cells from mice sacrificed on day 22 shows modestly reduced frequencies of IL-17 and IFN-γ producing CD3+ T cells in MCC950 treated mice in comparison with PBS-treated mice. IFN-γ and particularly IL-17 producing cell numbers are also reduced in both the CD4+ and γδ+ sub-populations of CD3+ T cells.
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-1 感染期间参与 CD4+ T 细胞的 caspase-1 激活，他们从 VIR 患者中获得的外周血单个核细胞，并使用 NLRP3 抑制剂（MCC950）与之共培养。结果表明，与对照组相比，MCC-950 的添加会显著抑制 CD4+ T 细胞 caspase-1 的激活、IL-1β 的分泌以及上清中乳酸脱氢酶的释放。 图片来源：JCI 研究总结 综上所述，在本研究中，研究人员探讨了 HIV-1 感染患者 CD4+ T 细胞焦亡和凋亡的发生及其临床意义，发现 CD4+ T 细胞的焦亡和凋亡与 HIV
controversial. In normal individuals, the removal of inhaled pathogens from the airway surface by mucociliary clearance (MCC) forms a major line of lung defense (16 ,17 ). In addition, the antimicrobial properties of airway surface liquid (ASL) contribute
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