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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1394076-92-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥523.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥476.0 |
| 规格： | 10 mg | 产品价格： | ￥800.0 |
| 规格： | 25 mg | 产品价格： | ￥1800.0 |
| 规格： | 50 mg | 产品价格： | ￥3000.0 |
| 规格： | 100 mg | 产品价格： | ￥4750.0 |
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GNE-317
CAS No. : 1394076-92-6
MCE 国际站：GNE-317
产品活性：GNE-317 是一种 PI3K/mTOR 抑制剂，能够穿过血脑屏障 (BBB)。
研究领域：PI3K/Akt/mTOR
In Vitro: GNE-317 is an oxetane derivative of GDC-0980 synthesized with the goal of reducing substrate affinity for efflux transporters. In vitro, GDC-0980 and GNE-317 demonstrate similar profiles in MTS cytotoxicity experiments using the GL261 cell line.
In Vivo: Seven days after i.c. inoculation with GL261-GFP-Luc cells, mice are treated once daily with the maximum tolerated dose of GDC-0980 (7.5 mg/kg), GNE-317 (30 mg/kg), or vehicle. For GL261, tumor growth is tracked through bioluminescence imaging on a weekly basis. There are no significant changes in GL261 tumor growth among the 3 groups. In assessing survival benefits in GL261, neither GDC-0980 nor GNE-317 provides survival benefit over the vehicle-treated animals. The fact that these drugs are not effective in vivo is suggested by the in vitro cytotoxicity data showing that the drugs have limited efficacy in inducing cell death in the GL261 cell line. Neither drug is effective in the GL261 tumor in spite of greater delivery and enhanced therapeutic targeting efficacy of GNE-317.
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文献和实验Onodera pp. 61 - 74 4. The Reference Point Method in Primer Design Thomas Kämpke pp. 75 - 92 5. PCR Primer Design Using Statistical Modeling Anton Yuryev pp. 93 - 104 6. Developing a Statistical Model for Primer Design Jianping Huang
4 )2 CO3 [g] 96.09 192.18 288.27 384.36 480.45 H2 O [ml] 935.21 868.92 800.63 729.84 654.75 %(w/w) 9.317 18.111 26.474 34.496 42.323 H2 O %(w/w) 90.683 81.889 73.526 65.504 57.677 p (g/ml) 15o C 1.0313
MMB.Vol.323_Arabidopsis_Protocols.rar MMB.Vol.315_Mast_Cells.rar MMB.Vol.303_Nanobiotechnology_protocols.rar MMB.Vol.317_Differential_Display_Methods_and_Protocols.rar MMB.Vol.301_Ubiquitin-Proteasome_Protocols.rar MMB.Vol.314_DNA_Repair
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