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- 2025年12月05日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CID-2950007
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
71203-35-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥294.0 |
| 规格： | 5 mg | 产品价格： | ￥700.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 25 mg | 产品价格： | ￥2400.0 |
| 规格： | 50 mg | 产品价格： | ￥3950.0 |
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ML141
CAS No. : 71203-35-5
MCE 国际站：ML141
产品活性：ML141 (CID-2950007) 是一种高效、变构、选择性、可逆的 Cdc42 GTPase 非竞争性抑制剂。ML141 抑制 Cdc42 野生型和 Cdc42 Q61L 突变体的 EC50 值分别为 2.1 和 2.6 μM。ML141 对 GTPases Rho 家族的其他成员 (Rac1, Rab2, Rab7) 表现出低的微极性和选择性。ML141 在多个细胞系中没有显示细胞毒性。
研究领域：GPCR/G Protein | Apoptosis
In Vitro: ML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively.
ML141 inhibits 3T3 fibroblast filopodia formation and inhibits ovarian cancer cell migration.
In Vivo: ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice.
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文献和实验Replication timing by density transfer
(frozen slanted to maximize the surface area). During the experiment, mix 20 ml of cells with 1/50 volume of 10% Na-azide in a 35 ml Corex tube (on ice) and immediately transfer the mix to a tube of frozen EDTA/azide. Alternatively, squirt the 10% azide
Replication timing by density transfer
(frozen slanted to maximize the surface area). During the experiment, mix 20 ml of cells with 1/50 volume of 10% Na-azide in a 35 ml Corex tube (on ice) and immediately transfer the mix to a tube of frozen EDTA/azide. Alternatively, squirt the 10% azide
2 1.2ml Trizol， lane3 1.5ml Trizol，lane4 2mlTrizol 以上用0.2倍体积氯仿，只用Trizol抽提一次 lane5 1ml Trizol，0.35体积氯仿，抽提一次 lane6 1ml Trizol, 0.35体积氯仿，抽提两次 lane7 1ml Trizol, 0.20体积氯仿，抽提两次 lane8 2ml Trizol，等体积氯仿 其中lane5为常规提取方法。 如果1-5有杂带，，67没有，说明是脑组织本身蛋白量和hnRNA过多
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