- ￥187 - 4300
- MedChemExpress(MCE)
- 美国
- HY-12452
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Diarylpropionitrile
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1428-67-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥187.0 |
| 规格： | 5 mg | 产品价格： | ￥375.0 |
| 规格： | 10 mg | 产品价格： | ￥600.0 |
| 规格： | 50 mg | 产品价格： | ￥2400.0 |
| 规格： | 100 mg | 产品价格： | ￥4300.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
DPN
CAS No. : 1428-67-7
MCE 国际站：DPN
产品活性：DPN (Diarylpropionitrile) 是一种非甾体雌激素受体 ERβ 选择性配体，其 EC50 值为 0.85 nM。DPN 在许多神经系统疾病具有神经保护作用。
研究领域：Vitamin D Related/Nuclear Receptor | Apoptosis | Autophagy
作用靶点：Estrogen Receptor/ERR | Apoptosis | Autophagy
In Vitro: DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC50=0.85 nM for ERβ; EC50=66 nM for ERα).
?DPN (10 nM) prevents morphological alterations from Aβ1-42 (10 μM)-induced toxicity in cultured cortical neurons.
?DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner.
?DPN (0.1-100 nM) significantly reduces Aβ1-42-stimulated expression of Bax in a non-dose dependent manner.
?DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ1-42 treatment on cultured cortical neurons.
?DPN (0.1-100 nM) suppresses the Aβ1-42-upregulated phosphorylation of JNK and p38.
In Vivo: DPN (10 μg; s.c.; daily; for 11 days) increases swimming and decreases immobility in the FST, and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model.
相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Autophagy Compound Library | Neuroprotective Compound Library | Anti-Breast Cancer Compound Library | Human Metabolite Library | Nuclear Receptor Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | LY294002 | Tamoxifen | Paclitaxel | Y-27632 | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | SB-431542 | Actinomycin D | Deferoxamine mesylate | Bortezomib | 5-Fluorouracil | Trametinib | Sorafenib | Oxaliplatin | Gemcitabine | Temozolomide | Rotenone | Mdivi-1 | Elesclomol | Ruxolitinib | Decitabine | SP600125 | MK-2206 dihydrochloride | Etoposide | Monomethyl auristatin E
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验是否最佳 4) DNA酶切位点上的碱基被甲基化 换用对DNA甲基化不敏感的同裂酶酶解，重新将质粒DNA转化至dcm-，dam-基因型的细菌菌株 5) DNA酶切位点上没有甲基化（如Dpn I） 换用不同切割非甲基化位点的同裂酶消化DNA（如San3A I代替Dpn I)，重新将质粒转至dcm+ dam+菌株中扩增
7iKmwcf6bs9SgOeZtX4nuJqEW/D/P9kDN4d/QZ30//NiwBEdf/iaSqijYeAKWLx+CSjlIDU0GjhrGrdGuVjHoJ/27L1V2Shy31K5dG6dPn5a+WHv06JEq80jKoL50xCLWkdJFCGaCT3RGX79+hc0xG9y4fh0XL17EoYMHJfuTLFmzwNDQCHXq1EHvvn3SpWAHEs2f37iEnDmJr7D5+PwQR9dtgQsKYVD3EhBivFr1rqim9hh2082
microscope (for measuring pipet length) Microfil (World Precision Instruments, cat. no. MF28G67‐5) 1‐ml syringes
技术资料暂无技术资料 索取技术资料
