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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
AS1413
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
69408-81-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥737.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥268.0 |
| 规格： | 5 mg | 产品价格： | ￥669.0 |
| 规格： | 10 mg | 产品价格： | ￥837.0 |
| 规格： | 25 mg | 产品价格： | ￥1758.0 |
| 规格： | 50 mg | 产品价格： | ￥2790.0 |
| 规格： | 100 mg | 产品价格： | ￥4669.0 |
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Amonafide
CAS No. : 69408-81-7
MCE 国际站：Amonafide
产品活性：Amonafide 是一种拓扑异构酶 II (topoisomerase II) 的抑制剂和 DNA 的嵌入剂，通过抑制 Topo II 与 DNA 的结合，来诱导凋亡信号通路的发生。
研究领域：Cell Cycle/DNA Damage
作用靶点：Topoisomerase
In Vitro: Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. Amonafide produces protein-associated DNA cleavage, single-strand breaks (SSB) and DPC and DNA double-strand cleavage. Amonafide (Nafidimide, 400 nM-2.4 μM) reduces the colony-forming ability of the leukemic cell lines in a dose-dependent manner. Amonafide (0.05-0.4 μg/mL) reduces several tumor growth. However, Amonafide is active against only 12% of tumors compared with standard agents (5-fluorouracil, mitomycin C, cisplatin, and etoposide), which are active against more than 40% of tumors in the human bone marrow inhibitory range. Amonafide inhibits the growth of HT-29, HeLa, and PC-3 cell lines, with IC50s of 4.67, 2.73, and 6.38 μM.
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