
大鼠肝微粒体 Rat Liver Microsomes
药物代谢稳定性实验/ADME实验/药理和药代相关实验研选同类产品更多 >
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- 保存条件:
-80℃
- 保质期:
2年
- 英文名:
Rat Liver Microsomes
- 库存:
大量
- 供应商:
齐氏生物
- CAS号:
详询
- 规格:
0.5ml、20mg/ml
肝微粒体是体外研究一个化合物的代谢(酶抑制,清除率和代谢鉴定)以及药物-药物相互作用的主要工具。通常根据特定细胞色素酶的活性水平来选择微粒体。
齐氏生物提供的肝细胞微粒体,每批产品都经过严格的制备、检测,确保批次间稳定性,然后于冻存管包装,10 mg/管;-80℃保存,干冰运输。
用途:ADME及药代动力学检测试验
种属:人/大鼠/小鼠/兔/狗/猪/猴 /牛/鱼
规格:0.5ml 20mg/ml
运输:冻存管,干冰运输。
微粒体产品被SCI论文引用(部分):
1.Metabolism of chicoric acid by rat liver microsomes and bioactivity comparisons of chicoric acid and its metabolites
Q Liu, Y Wang, CX Xiao, W Wu, X Liu - Food & function, 2015 - pubs.rsc.org
… 11–14 Moreover, chicoric acid has showed anti-inflammatory, anti-bacterial, anti-HIV
activities, hypoglycemic and hepatocyte protective properties … Rat liver microsomes
were obtained from CHI Scientific, Inc. (Massachusetts, USA)
2.Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy
C Huang, J Zheng, D Ma, N Liu, C Zhu, J Li… - Journal of Materials …, 2018 - pubs.rsc.org
… Rat liver microsomes were purchased from CHI Scientific (Jiangsu China … under hypoxic conditions
(red curve); DDS in the presence of inactive rat liver microsomes and NADPH … 0 represent the
fluorescence intensity of TAMRA after and before rat liver microsome addition under …
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文献和实验Q Liu, Y Wang, CX Xiao, W Wu, X Liu - Food & function, 2015 - pubs.rsc.org
… 11–14 Moreover, chicoric acid has showed anti-inflammatory, anti-bacterial, anti-HIV
activities, hypoglycemic and hepatocyte protective properties … Rat liver microsomes
were obtained from CHI Scientific, Inc. (Massachusetts, USA)
文章链接:https://doi.org/10.1039/C5FO00073D

2. Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy
C Huang, J Zheng, D Ma, N Liu, C Zhu, J Li… - Journal of Materials …, 2018 - pubs.rsc.org
… Rat liver microsomes were purchased from CHI Scientific (Jiangsu China … under hypoxic conditions
(red curve); DDS in the presence of inactive rat liver microsomes and NADPH … 0 represent the
fluorescence intensity of TAMRA after and before rat liver microsome addition under …
文章链接:https://doi.org/10.1039/C8TB01805G

This protocol describes the purification of mitochondria from rat liver with the aid of zone electrophoresis in a free flow device (ZE-FFE). Starting from liver homogenate, cell debris and nuclei are removed by low speed centrifugation
。人类的miR-2861是保守的,而在两例青少年患者中发现,pre-miR-2861的突变型纯合子导致的miR-2861表达受阻会引起原发性骨质疏松症,且在这两位患者的骨样品中,HDAC5和RUNX2的表达水平也有相应的上升或下降。 实验方法与结果: 6周龄的卵巢切除小鼠连续三天尾静脉注射micrOFFTM antagomir-2861(80 mg/kg体重),再在第4天、第3周及第6周收集股骨检测HDAC5蛋白表达水平及骨形成相关指标。
( 2 – 4 ), and rat-liver microsomes ( 3 – 5 ). A biological marker that indicates oxidative stress with respect to lipid peroxidation in body fluids or cells is malondialdehyde (MDA). MDA is a byproduct of the arachidonate cycle, as well as lipid
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