Socs 1 Antibody
Cat#:PL0305229
Isotype:Rabbit Polyclonal IgG
Immunogen:Peptide derived from human Socs 1.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor(LIF). Regulates interferon-gamma mediated sensory neuron survival. Implicated, through SOCS box binding, in ubiquitin-dependent protein degradation.
Alternate Names:
CISH 1; CISH1; Cytokine Inducible SH2 Protein 1; JAB; JAK Binding Protein; Janus kinase binding protein; SOCS 1; SOCS1; SOCS-1; SSI 1; SSI1; STAT Induced STAT Inhibitor 1; Supressor of cytokine Signalling 1; TEC Interacting Protein 3; TIP 3; TIP3; SOCS1_HUMAN.
Specificity Reaction:Hu, Mo, Rat, Pig, Cow, Hor,
Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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