Phospho-PAK1(Thr423)/PAK2 (Thr402) Antibody
Cat#:PL0304591
Isotype:Rabbit Polyclonal IgG
Immunogen:PhosphoPeptide derived from human PAK1 around the phosphorylation site of Thr423.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
In mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and PAK3 are mostly brain specific, while PAK2 is expressed ubiquitously. Mutations of the gene coding for PAK3 are associated with X linked mental retardation and PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK3 is thought to play a key role in regulation of cell shape and motility as well as cell death. P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage.
Alternate Names:
PAK1 + PAK2 + PAK3 (phospho T423 + T402 + T421); PAK1 + PAK2 + PAK3 (phospho Thr423 + Thr402 + Thr421); Pak2(phospho T402); Pak1(phospho T423); PAK1(phospho T402); PAK2(phospho T423); PAKalpha; serine/threonine-protein kinase PAK 1; p21 activated kinase 1; PAK alpha; Paka; PAKalpha; Protein kinase MUK2; STE20 homolog (yeast); Alpha PAK; p21/Cdc42/Rac1 activated kinase 1; CB422; EC 2.7.11.1; Gamma PAK; hPAK65; Kinase; p21 (CDKN1A)-activated kinase 2a; p21 activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein Cdc42 Rac activated kinase 2; p21-activated kinase, 65-KD; p21-activated protein kinase I; p21CDKN1A activated kinase 2; p58; p65PAK; PAK 2; PAK65; PAKgamma; S6 H4 kinase; Serine threonine protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; p21-activated kinase 3; PAK-3; Beta-PAK; PAK1_HUMAN; PAK2_HUMAN.
Specificity Reaction:Hu, Mo, Rat, Chi, Dog, Pig, Cow,
Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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