- ￥2400
- PL Laboratories
- 加拿大
- PL0402564
- 2025年07月11日
- WB: 1:100-500 IHC: 1:500-1000
- Rabbit
- Mo，Rat
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- 详细信息
- 技术资料
- 免疫原：
peptide corresponding to a sequence at the N-terminus of mouse MEKK3.
- 亚型：
Rabbit Polyclonal IgG
- 形态：
液态
- 保存条件：
保存于-20℃
- 克隆性：
多克隆
- 标记物：
无标记（PLlabs可供应生物素、酶、荧光素标记的抗体）
- 适应物种：
Mo，Rat
- 保质期：
按说明书条件可保存1-2年
- 抗原来源：
见详细说明资料
- 目录编号：
PL0402564
- 级别：
超纯
- 库存：
大量
- 供应商：
华拓生物
- 宿主：
Rabbit
- 应用范围：
WB: 1:100-500 IHC: 1:500-1000
- 浓度：
1mg/ml
- 靶点：
MAP3K3
- 抗体英文名：
MAP3K3 Antibody
- 抗体名：
MAP3K3抗体
- 规格：
0.1ml
MAP3K3 Antibody
Cat#：PL0402564
Isotype:Rabbit Polyclonal IgG
Immunogen：peptide corresponding to a sequence at the N-terminus of mouse MEKK3.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background：
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background：
MAP3K3(Mitogen-activated protein kinase kinase kinase 3), also known as MAP/ERK KINASE KINASE 3, MEKK3 or MAPKKK3, is an enzyme that in humans is encoded by the MAP3K3 gene. MAP3K3 is contiguously distal to LYK5 on chromosome 17(Puffenberger et al., 2007). By yeast 2-hybrid analysis of a mouse T-cell cDNA library, Uhlik et al.(2003) showed that a C-terminal fragment of mouse Osm(CCM2) interacted with Mekk3, which activates p38 in response to sorbitol-induced hyperosmotic conditions. Mekk3 and Osm colocalized in the cytoplasmic compartment of cotransfected cells, and the Mekk3-Osm complex was recruited to Rac1 and cytoskeletal actin-containing membrane ruffles in response to sorbitol treatment. Protein interaction assays showed that Osm interacted directly with the Mekk3 substrate Mkk3(MAP2K3), with actin, and with both GDP- and GTP-loaded Rac1.
Alternate Names：
M3K3_HUMAN antibody;MAP/ERK kinase kinase 3 antibody;MAP3K3 antibody;MAPK/ERK kinase kinase 3 antibody;MAPKKK3 antibody;MEK kinase 3 antibody;MEKK 3 antibody.
Specificity Reaction：Mo，Rat
Application Notes:WB: 1:100-500 IHC: 1:500-1000
Storage ：
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
PLlabs公司可供应相应抗体的生物素、辣根过氧化物酶、荧光素（FITC、PE、 CY3、 CY5、 CY7、 PE- CY3/5/7)标记抗体，欢迎大家咨询订购。
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MAP3K3抗体
￥2400
