- ￥2400
- PL Laboratories
- 加拿大
- PL0402185
- 2025年07月14日
- WB: 1:100-500 IHC: 1:500-1000
- Rabbit
- Hu，Rat
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- 详细信息
- 技术资料
- 免疫原：
peptide corresponding to a sequence at the C-terminus of human Cdc25B.
- 亚型：
Rabbit Polyclonal IgG
- 形态：
液态
- 保存条件：
保存于-20℃
- 克隆性：
多克隆
- 标记物：
无标记（PLlabs可供应生物素、酶、荧光素标记的抗体）
- 适应物种：
Hu，Rat
- 保质期：
按说明书条件可保存1-2年
- 抗原来源：
见详细说明资料
- 目录编号：
PL0402185
- 级别：
超纯
- 库存：
大量
- 供应商：
华拓生物
- 宿主：
Rabbit
- 应用范围：
WB: 1:100-500 IHC: 1:500-1000
- 浓度：
1mg/ml
- 靶点：
CDC25B
- 抗体英文名：
CDC25B Antibody
- 抗体名：
CDC25B抗体
- 规格：
0.1ml
CDC25B Antibody
Cat#：PL0402185
Isotype:Rabbit Polyclonal IgG
Immunogen：peptide corresponding to a sequence at the C-terminus of human Cdc25B.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background：
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background：
Central to the onset of mitosis in all eukaryotic cells is the CDC2 protein kinase, the activity of which is negatively regulated by phosphorylation and positively activated by dephosphorylation. The latter function is carried out by a specific phosphatase, CDC25. At least 3 human CDC25 genes code for the A, B, and C forms of CDC25. CDC25B is mapped to 20p13. P38 kinase has a critical role in the initiation of a G2 delay after ultraviolet radiation. Inhibition of p38 blocks the rapid initiation of this checkpoint in both human and murine cells after ultraviolet radiation. In vitro, p38 binds and phosphorylates CDC25B at serines 309 and 361, and CDC25C at serine-216; phosphorylation of these residues is required for binding to 14-3-3 proteins. In vivo, inhibition of p38 prevents both phosphorylation of CDC25B at serine-309 and 14-3-3 binding after ultraviolet radiation, and mutation of this site is sufficient to inhibit the checkpoint initiation.
Alternate Names：
Cdc25b antibody;CDC25B1 antibody;CDC25B2 antibody;CDC25B3 antibody;CDC25HU2 antibody;Cdc25m2 antibody;Cell division cycle 25 homolog B antibody;Cell division cycle 25B antibody.
Specificity Reaction：Hu，Rat
Application Notes:WB: 1:100-500 IHC: 1:500-1000
Storage ：
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
PLlabs公司可供应相应抗体的生物素、辣根过氧化物酶、荧光素（FITC、PE、 CY3、 CY5、 CY7、 PE- CY3/5/7)标记抗体，欢迎大家咨询订购。
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CDC25B抗体
￥2400
