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- 国食药监械注册号:
无
- 库存:
大量
- 供应商:
玉研仪器公司
- 现货状态:
现货供应大小鼠监护仪
- 保修期:
大鼠监护仪,小鼠监护仪,动物监护仪,小动物监护仪
- 规格:
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玉研仪器公司作为Mouse Ox Plus 小动物脉搏血氧仪产品的中国区总代理,该仪器适用于小鼠、大鼠、豚鼠、兔子等动物,可以在清醒或麻醉状态下测量动物的脉搏、血氧、呼吸、体温等多种生理参数。
· 小动物脉搏血氧仪可用于多参数数据的采集或手术监护,可拓展多通道大鼠、小鼠的生理信号测量仪;
· 以无创的方式测量小动物(幼鼠,小鼠,大鼠,豚鼠,兔, 等)的血氧饱和度、脉搏频率、呼吸频率、脉搏幅度、呼吸幅度和体温;
· 除体温外,所有测量都是通过一个无创的感应器。
所有测量都是通过一个无创的感应器完成,准确、方便、高效。
型号:MouseOx 正在对麻醉状态下的小鼠进行测试
有多种探头可供选择:
· 根据实验需求:可选择大鼠型探头、小鼠型探头;
· 根据动物状态:可选择清醒活动状态连续测量和麻醉(或手术)状态测量探头;
· 根据动物数量:有多通道适配器可供选择,同时检测多只动物的生命体征;
· 根据使用环境:可选择核磁环境适用的无磁探头;
主要功能:
· 小动物手术术中监测(保证适当的麻醉深度,防止手术中缺氧)
· 一个无创传感器获得多个生命信号 (动脉血氧饱和度,心率,呼吸频率,脉搏幅度,呼吸幅度)
· 心肺功能参数记录
· 输出模拟数据
经过验证的准确度:
使用有创血气采样测量结果与无创 MouseOx 测量结果的比较, 对比表明, 两者具有很好的线性关系。
脉搏、血氧、呼吸等心肺监测参数:
· 脉波频率在90到900BPM范围内监测 (每分钟心跳, Beat per minutes, BPM)
· 血氧饱和度监测范围:0% 到100% 动脉血氧饱和度;
· 血氧饱和度监测误差:<1.5% 横跨整个监测范围;
· 血氧饱和度监测反应时间:实时报告动脉血氧饱和度, 在每次心跳以后0.72秒屏幕刷新;
· 呼吸频率监测范围:每分钟 25到450 次;
· 监测反应时间:呼吸率每1.7秒向用户报告, 移动报告的值是10次呼吸的的平均数;
· 无创伤监测脉搏充盈度以估量血流量的变化;
· 脉搏监测范围:内径0到800微米的徽小血管;
· 监测误差:< 2.4%横跨整个监测范围;
· 监测反应时间:脉搏充盈度实时向用户报告, 在每次心跳以后,0.72秒屏幕刷新,刷新屏幕显示被测量的所有脉搏充盈度;
· 无创伤监测动物呼吸幅度的变化;
· 呼吸幅度监测范围:每分钟25到450次;
· 呼吸幅度监测反应时间:呼吸率每1.7秒向用户报告, 移动报告的值是10次呼吸的的平均数;

多钟测试探头可选:
根据需要,可选择老鼠清醒状态下使用的颈部探头,麻醉状态下使用的足部探头和大腿探头
以下是使用有创血气采样测量结果与无创MouseOx测量结果的比较
可实现大鼠、小鼠清醒活动状态下进行测量
软件界面
小动物脉搏血氧监护仪的部分参考文献:
1. Albéri, L., Lintas, A., Kretz, R., Schwaller, B., & Villa, A. E. (2013). The calcium-binding protein parvalbumin modulates the firing 1 properties of the reticular thalamic nucleus bursting neurons. Journal of neurophysiology, 109(11), 2827-2841.
2. Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’Connor, T., Hornemann, S., Aguzzi, A. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102-106.
3. Ali, I., O’Brien, P., Kumar, G., Zheng, T., Jones, N. C., Pinault, D., O’Brien, T. J. (2013). Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy. PLOS ONE, 8(6), e66962.
4. Bell, L. A., Bell, K. A., & McQuiston, A. R. (2013). Synaptic Muscarinic Response Types in Hippocampal CA1 Interneurons Depend on Different Levels of Presynaptic Activity and Different Muscarinic Receptor Subtypes. Neuropharmacology.
5. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.
6. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.
7. Babaei, P., Tehrani, B. S., & Alizadeh, A. (2013). Effect of BDNF and adipose derived stem cells transplantation on cognitive deficit in Alzheimer model of rats. Journal of Behavioral and Brain Science, 3, 156-161.
8. Gilmartin, M. R., Miyawaki, H., Helmstetter, F. J., & Diba, K. (2013). Prefrontal Activity Links Nonoverlapping Events in Memory. The Journal of Neuroscience, 33(26), 10910-10914.
9. Feng, L., Sametsky, E. A., Gusev, A. G., & Uteshev, V. V. (2012). Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target. Journal of Neurophysiology, 108(7), 1884-1894.
10. Clarner, T., Diederichs, F., Berger, K., Denecke, B., Gan, L., Van der Valk, P., Kipp, M. (2012). Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions. Glia, 60(10), 1468-1480.
11. Girardet, C., Bonnet, M. S., Jdir, R., Sadoud, M., Thirion, S., Tardivel, C., Troadec, J. D. (2011). Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: A PGE2-independent mechanism.Toxicological Sciences, 124(1), 179-191.
12. Hruška-Plocháň, M., Juhas, S., Juhasova, J., Galik, J., Miyanohara, A., Marsala, M., Motlik, J. (2010). A27 Expression of the human mutant huntingtin in minipig striatum induced formation of EM48+ inclusions in the neuronal nuclei, cytoplasm and processes. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.
13. Brooks, S., Jones, L., & Dunnett, S. B. (2010). A29 Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A10.
14. Yu, L., Metzger, S., Clemens, L. E., Ehrismann, J., Ott, T., Gu, X., Nguyen, H. P. (2010). A28 Accumulation and aggregation of human mutant huntingtin and neuron atrophy in BAC-HD transgenic rat. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.
15. Baxa, M., Juhas, S., Pavlok, A., Vodicka, P., Juhasova, J., Hruška-Plocháň, M., Motlik, J. (2010). A26 Transgenic miniature pig as an animal model for Huntington’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A8-A9.
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文献和实验小动物脉搏血氧监护仪的部分参考文献:
1. Albéri, L., Lintas, A., Kretz, R., Schwaller, B., & Villa, A. E. (2013). The calcium-binding protein parvalbumin modulates the firing 1 properties of the reticular thalamic nucleus bursting neurons. Journal of neurophysiology, 109(11), 2827-2841.
2. Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’Connor, T., Hornemann, S., Aguzzi, A. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102-106.
3. Ali, I., O’Brien, P., Kumar, G., Zheng, T., Jones, N. C., Pinault, D., O’Brien, T. J. (2013). Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy. PLOS ONE, 8(6), e66962.
4. Bell, L. A., Bell, K. A., & McQuiston, A. R. (2013). Synaptic Muscarinic Response Types in Hippocampal CA1 Interneurons Depend on Different Levels of Presynaptic Activity and Different Muscarinic Receptor Subtypes. Neuropharmacology.
5. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.
6. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.
7. Babaei, P., Tehrani, B. S., & Alizadeh, A. (2013). Effect of BDNF and adipose derived stem cells transplantation on cognitive deficit in Alzheimer model of rats. Journal of Behavioral and Brain Science, 3, 156-161.
8. Gilmartin, M. R., Miyawaki, H., Helmstetter, F. J., & Diba, K. (2013). Prefrontal Activity Links Nonoverlapping Events in Memory. The Journal of Neuroscience, 33(26), 10910-10914.
9. Feng, L., Sametsky, E. A., Gusev, A. G., & Uteshev, V. V. (2012). Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target. Journal of Neurophysiology, 108(7), 1884-1894.
10. Clarner, T., Diederichs, F., Berger, K., Denecke, B., Gan, L., Van der Valk, P., Kipp, M. (2012). Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions. Glia, 60(10), 1468-1480.
11. Girardet, C., Bonnet, M. S., Jdir, R., Sadoud, M., Thirion, S., Tardivel, C., Troadec, J. D. (2011). Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: A PGE2-independent mechanism.Toxicological Sciences, 124(1), 179-191.
12. Hruška-Plocháň, M., Juhas, S., Juhasova, J., Galik, J., Miyanohara, A., Marsala, M., Motlik, J. (2010). A27 Expression of the human mutant huntingtin in minipig striatum induced formation of EM48+ inclusions in the neuronal nuclei, cytoplasm and processes. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.
13. Brooks, S., Jones, L., & Dunnett, S. B. (2010). A29 Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A10.
14. Yu, L., Metzger, S., Clemens, L. E., Ehrismann, J., Ott, T., Gu, X., Nguyen, H. P. (2010). A28 Accumulation and aggregation of human mutant huntingtin and neuron atrophy in BAC-HD transgenic rat. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.
15. Baxa, M., Juhas, S., Pavlok, A., Vodicka, P., Juhasova, J., Hruška-Plocháň, M., Motlik, J. (2010). A26 Transgenic miniature pig as an animal model for Huntington’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A8-A9.
、耐心、少食多餐,以免导致呛咳、气促、呼吸困难等,必要时从静脉补充营养。 4.观察病情变化,防止并发症发生。 (l)注意心率、心律、脉搏、呼吸、血压及心杂音变化,必要时使用监护仪监测。 (2)防止法洛四联症患儿因哭闹、进食、活动排便等引起缺氧发作,一旦发生可立即置于膝胸卧位,吸氧,通知医师,并做好普萘洛尔、吗啡应用和纠正酸中毒等准备。 (3)青紫型先天性心脏病患儿,由于血液粘稠度高,暑天、发热、多汗、吐泻时体液量减少,加重血液浓缩,易
,动物在笼子中饲养一周,以适应环境。用戊巴比妥钠腹腔内注射麻醉(35mg/kg)。每只大鼠均俯卧位置于加热板上,手术在严格无菌条件下进行。体温保持在37°C,血压用无创血压监护仪监护,以保持术中平稳的生理状态。以C4棘突为中心,做一纵行皮肤切口,从锥板上钝性两侧椎旁肌。暴露双侧锥板,在显微镜下分离出C4、C5根部,并切除。然后,切除C4棘突,实行椎板去皮质术。C4左侧从侧面牵拉到一侧,聚乙烯通过C4椎体的腹侧,固定在一块1*2*0.5mm 大小的抵在C4椎体腹侧上的塑料片上,然后缠绕三圈固定
一、不同实验动物采血方法的选择决定于实验目的所需血量以及动物种类。凡用血量较少的检验如红、白细胞计数、血红蛋白的测定,血液涂片以及酶活性微量分析法等,可刺破组织取毛细血管的血。当需血量较多时可作静脉采血。静脉采血时,若需反复多次,应自远离心脏端开始,以免发生栓塞而影响整条静脉。而研究毒物对肺功能的影响、血液酸碱平衡、水盐代谢紊乱,需要比较动、静脉血氧分压、二氧化碳分压和血pH值以及K+、Na+、Cl-离子浓度,必须采取动脉血液。(一)、大、小鼠的采血方法1、颈静脉或颈动脉采血2、股静脉或股
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