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- 详细信息
- 文献和实验
- 技术资料
- 库存:
100
- 国食药监械注册号:
无
- 保修期:
小鼠血氧仪,小鼠血氧测量仪
- 现货状态:
现货
- 供应商:
玉研仪器公司
- 规格:
敬请来电咨询
玉研仪器公司作为Mouse Ox Plus 小动物脉搏血氧仪产品的中国区总代理,该仪器适用于小鼠、大鼠、豚鼠、兔子等动物,可以在清醒或麻醉状态下测量动物的脉搏、血氧、呼吸、体温等多种生理参数。
· 小动物脉搏血氧仪可用于多参数数据的采集或手术监护,可拓展多通道大鼠、小鼠的生理信号测量仪;
· 以无创的方式测量小动物(幼鼠,小鼠,大鼠,豚鼠,兔, 等)的血氧饱和度、脉搏频率、呼吸频率、脉搏幅度、呼吸幅度和体温;
· 除体温外,所有测量都是通过一个无创的感应器。
所有测量都是通过一个无创的感应器完成,准确、方便、高效。
型号:MouseOx 正在对麻醉状态下的小鼠进行测试
有多种探头可供选择:
· 根据实验需求:可选择大鼠型探头、小鼠型探头;
· 根据动物状态:可选择清醒活动状态连续测量和麻醉(或手术)状态测量探头;
· 根据动物数量:有多通道适配器可供选择,同时检测多只动物的生命体征;
· 根据使用环境:可选择核磁环境适用的无磁探头;
主要功能:
· 小动物手术术中监测(保证适当的麻醉深度,防止手术中缺氧)
· 一个无创传感器获得多个生命信号 (动脉血氧饱和度,心率,呼吸频率,脉搏幅度,呼吸幅度)
· 心肺功能参数记录
· 输出模拟数据
经过验证的准确度:
使用有创血气采样测量结果与无创 MouseOx 测量结果的比较, 对比表明, 两者具有很好的线性关系。
脉搏、血氧、呼吸等心肺监测参数:
· 脉波频率在90到900BPM范围内监测 (每分钟心跳, Beat per minutes, BPM)
· 血氧饱和度监测范围:0% 到100% 动脉血氧饱和度;
· 血氧饱和度监测误差:<1.5% 横跨整个监测范围;
· 血氧饱和度监测反应时间:实时报告动脉血氧饱和度, 在每次心跳以后0.72秒屏幕刷新;
· 呼吸频率监测范围:每分钟 25到450 次;
· 监测反应时间:呼吸率每1.7秒向用户报告, 移动报告的值是10次呼吸的的平均数;
· 无创伤监测脉搏充盈度以估量血流量的变化;
· 脉搏监测范围:内径0到800微米的徽小血管;
· 监测误差:< 2.4%横跨整个监测范围;
· 监测反应时间:脉搏充盈度实时向用户报告, 在每次心跳以后,0.72秒屏幕刷新,刷新屏幕显示被测量的所有脉搏充盈度;
· 无创伤监测动物呼吸幅度的变化;
· 呼吸幅度监测范围:每分钟25到450次;
· 呼吸幅度监测反应时间:呼吸率每1.7秒向用户报告, 移动报告的值是10次呼吸的的平均数;

多钟测试探头可选:
根据需要,可选择老鼠清醒状态下使用的颈部探头,麻醉状态下使用的足部探头和大腿探头
以下是使用有创血气采样测量结果与无创MouseOx测量结果的比较
可实现大鼠、小鼠清醒活动状态下进行测量
软件界面
小动物脉搏血氧监护仪的部分参考文献:
1. Albéri, L., Lintas, A., Kretz, R., Schwaller, B., & Villa, A. E. (2013). The calcium-binding protein parvalbumin modulates the firing 1 properties of the reticular thalamic nucleus bursting neurons. Journal of neurophysiology, 109(11), 2827-2841.
2. Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’Connor, T., Hornemann, S., Aguzzi, A. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102-106.
3. Ali, I., O’Brien, P., Kumar, G., Zheng, T., Jones, N. C., Pinault, D., O’Brien, T. J. (2013). Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy. PLOS ONE, 8(6), e66962.
4. Bell, L. A., Bell, K. A., & McQuiston, A. R. (2013). Synaptic Muscarinic Response Types in Hippocampal CA1 Interneurons Depend on Different Levels of Presynaptic Activity and Different Muscarinic Receptor Subtypes. Neuropharmacology.
5. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.
6. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.
7. Babaei, P., Tehrani, B. S., & Alizadeh, A. (2013). Effect of BDNF and adipose derived stem cells transplantation on cognitive deficit in Alzheimer model of rats. Journal of Behavioral and Brain Science, 3, 156-161.
8. Gilmartin, M. R., Miyawaki, H., Helmstetter, F. J., & Diba, K. (2013). Prefrontal Activity Links Nonoverlapping Events in Memory. The Journal of Neuroscience, 33(26), 10910-10914.
9. Feng, L., Sametsky, E. A., Gusev, A. G., & Uteshev, V. V. (2012). Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target. Journal of Neurophysiology, 108(7), 1884-1894.
10. Clarner, T., Diederichs, F., Berger, K., Denecke, B., Gan, L., Van der Valk, P., Kipp, M. (2012). Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions. Glia, 60(10), 1468-1480.
11. Girardet, C., Bonnet, M. S., Jdir, R., Sadoud, M., Thirion, S., Tardivel, C., Troadec, J. D. (2011). Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: A PGE2-independent mechanism.Toxicological Sciences, 124(1), 179-191.
12. Hruška-Plocháň, M., Juhas, S., Juhasova, J., Galik, J., Miyanohara, A., Marsala, M., Motlik, J. (2010). A27 Expression of the human mutant huntingtin in minipig striatum induced formation of EM48+ inclusions in the neuronal nuclei, cytoplasm and processes. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.
13. Brooks, S., Jones, L., & Dunnett, S. B. (2010). A29 Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A10.
14. Yu, L., Metzger, S., Clemens, L. E., Ehrismann, J., Ott, T., Gu, X., Nguyen, H. P. (2010). A28 Accumulation and aggregation of human mutant huntingtin and neuron atrophy in BAC-HD transgenic rat. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.
15. Baxa, M., Juhas, S., Pavlok, A., Vodicka, P., Juhasova, J., Hruška-Plocháň, M., Motlik, J. (2010). A26 Transgenic miniature pig as an animal model for Huntington’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A8-A9.
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文献和实验· Calibration and Validation of the MouseOx® Small-Animal Pulse Oximeter
Kingman P. Strohl* MD, David Baekey* PhD, Susan Dase** MS and Bernie Hete** PhD.
*Department of Pulmonary and Critical Care Medicine, Case Western Reserve University
**Department of Engineering, STARR Life Sciences Corp.
· Transfusion-related Acute Lung Injury
Chelsea A. Sheppard, MDa, Lennart E. Lo¨ gdberg, MD, PhDa, James C. Zimring, MD, PhDa, Christopher D. Hillyer, MDb,
aDepartment of Pathology and Laboratory Medicine, Room D-655, Emory University School of Medicine, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
bDepartment of Pathology and Laboratory Medicine, Transfusion Medicine Program, Room D-655, Emory University Hospital, 1364 Clifton Road, NE, Atlanta, GA 30322, USAHEMATOLOGY/ONCOLOGY CLINICS OF NORTH AMERICA
· Epidermal Sensing of Oxygen Is Essential for Systemic Hypoxic Response
Adam T. Boutin,1 Alexander Weidemann,1 Zhenxing Fu,5 Lernik Mesropian,1
Katarina Gradin,2 Colin Jamora,1 Michael Wiesener,3 Kai-Uwe Eckardt,3 Cameron J. Koch,4 Lesley G. Ellies,5
Gabriel Haddad,5 Volker H. Haase,4 M. Celeste Simon,4 Lorenz Poellinger,2 Frank L. Powell,5 and Randall S. Johnson1
1Molecular Biology Section, Division of Biological Sciences, UC San Diego, La Jolla, CA 92093, USA
2Karolinska Institute, Stockholm S-17177, Sweden
3University of Erlangen, Erlangen D-91054, Germany
4University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
5Departments of Medicine, Pediatrics, and Pathology, UC San Diego School of Medicine, La Jolla 92093 CA, USA
· Age-related cardiac muscle sarcopenia: Combining experimental
and mathematical modeling to identify mechanisms
Jing Lin a,b, Elizabeth F. Lopez a,c, Yufang Jin f, Holly Van Remmen d,e, Terry Bauch a, Hai-Chao Han g, Merry L. Lindsey a,b,d,e
aDivision of Cardiology, Department of Medicine, The University of Texas Health Science Center at San Antonio (UTHSCSA),
7703 Floyd Curl Dr., MC-7872, San Antonio, TX 78229, USA
bThe Janey Briscoe Center of Excellence in Cardiovascular Research, UTHSCSA, USA
cJohn Jay Science and Engineering Academy, UTHSCSA, USA
dThe Barshop Institute for Longevity and Aging Studies, UTHSCSA, USA
eDepartment of Cellular and Structural Biology, UTHSCSA, USA
fDepartment of Electrical Engineering, UTSA, USA
gDepartment of Mechanical Engineering, UTSA, USA
· Post infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection
Ian C. Davis1, Eduardo R. Lazarowski2, Fu-Ping Chen3, Judy M. Hickman-Davis1, Wayne M. Sullender3,4, and Sadis Matalon1,4,5
1 Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
2 Department of Medicine, UNC, Chapel Hill, NC, USA
3 Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
4 Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
5 Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
小动物脉搏血氧监护仪的部分参考文献:
1. Albéri, L., Lintas, A., Kretz, R., Schwaller, B., & Villa, A. E. (2013). The calcium-binding protein parvalbumin modulates the firing 1 properties of the reticular thalamic nucleus bursting neurons. Journal of neurophysiology, 109(11), 2827-2841.
2. Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’Connor, T., Hornemann, S., Aguzzi, A. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102-106.
3. Ali, I., O’Brien, P., Kumar, G., Zheng, T., Jones, N. C., Pinault, D., O’Brien, T. J. (2013). Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy. PLOS ONE, 8(6), e66962.
4. Bell, L. A., Bell, K. A., & McQuiston, A. R. (2013). Synaptic Muscarinic Response Types in Hippocampal CA1 Interneurons Depend on Different Levels of Presynaptic Activity and Different Muscarinic Receptor Subtypes. Neuropharmacology.
5. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.
6. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.
7. Babaei, P., Tehrani, B. S., & Alizadeh, A. (2013). Effect of BDNF and adipose derived stem cells transplantation on cognitive deficit in Alzheimer model of rats. Journal of Behavioral and Brain Science, 3, 156-161.
8. Gilmartin, M. R., Miyawaki, H., Helmstetter, F. J., & Diba, K. (2013). Prefrontal Activity Links Nonoverlapping Events in Memory. The Journal of Neuroscience, 33(26), 10910-10914.
9. Feng, L., Sametsky, E. A., Gusev, A. G., & Uteshev, V. V. (2012). Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target. Journal of Neurophysiology, 108(7), 1884-1894.
10. Clarner, T., Diederichs, F., Berger, K., Denecke, B., Gan, L., Van der Valk, P., Kipp, M. (2012). Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions. Glia, 60(10), 1468-1480.
11. Girardet, C., Bonnet, M. S., Jdir, R., Sadoud, M., Thirion, S., Tardivel, C., Troadec, J. D. (2011). Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: A PGE2-independent mechanism.Toxicological Sciences, 124(1), 179-191.
12. Hruška-Plocháň, M., Juhas, S., Juhasova, J., Galik, J., Miyanohara, A., Marsala, M., Motlik, J. (2010). A27 Expression of the human mutant huntingtin in minipig striatum induced formation of EM48+ inclusions in the neuronal nuclei, cytoplasm and processes. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.
13. Brooks, S., Jones, L., & Dunnett, S. B. (2010). A29 Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A10.
14. Yu, L., Metzger, S., Clemens, L. E., Ehrismann, J., Ott, T., Gu, X., Nguyen, H. P. (2010). A28 Accumulation and aggregation of human mutant huntingtin and neuron atrophy in BAC-HD transgenic rat. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.
15. Baxa, M., Juhas, S., Pavlok, A., Vodicka, P., Juhasova, J., Hruška-Plocháň, M., Motlik, J. (2010). A26 Transgenic miniature pig as an animal model for Huntington’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A8-A9.
清醒大鼠的血压测定有多种方法。按是否进行手术分为有创和无创;按测定方式分为直接和间接,一般直接法都是有创的。 直接法又分为导管法和换能器埋入腹腔遥测法,前者插入大鼠动脉的导管通过换能器与记录系统有连接,测量时清醒大鼠的活动受一定的限制,后者插入动脉的导管、换能器与记录系统无任何连接,测量时大鼠可自由活动。 间接法一般是无创的,间接法有多种,常用的有鼠尾容积测压法和大鼠尾动脉脉搏测压法等等。目前,清醒大鼠血压测定方法多为大鼠尾动脉脉搏测压
在过去20年中,研究科学家们一直在寻找更加精确的无创测量小鼠或大鼠血压的方法。更加精确的用无创的方法测量啮齿动物的收缩压、舒张压、心率、和其他一些血流的参数,对于临床研究是很有价值的。 一、有创方法测量血压 有创血压是评价无创血压的金标准。当评价无创血压时,有创血压的测量是从动物颈动脉测量的。 利用遥测方法测量到血压也是非常可靠和精确的,它也被用来评价无创血压的真实性。这种方法通过在动物体内埋藏植入子来测量无创血压,这种方法测量到的动物血压与直接方法测量的血压
多在夜间发生。4、大鼠对空气中的粉尘、氨气、硫化氢等极为敏感,易引发呼吸道疾病,一般开放饲养的大鼠主要死因为呼吸道疾病。5、大鼠对各种刺激很敏感,环境条件的微小变化也可引起大鼠的反应,强烈的噪音可导致大鼠恐慌、互相撕咬,带仔母鼠可出现吃仔现象。6、大鼠具有群居优势,同笼多个饲养比单个饲养的大鼠体重增长快、性情温顺、易于捉取,单个饲养的则胆小易惊、不易捕捉。二、解剖学特点1、外观 大鼠外观与小鼠相似,但个体较大。一般成年大鼠体长不小于18~20cm。尾上覆有短毛和环状角质鳞片,数量多于200片。上下颌
技术资料









