Porcine Antithrombin III

抗凝血酶III（Antithrombin，AT-III）的生理功能与临床应用

抗凝血酶III（Antithrombin，AT-III）概述 抗凝血酶III（AT-III），又称抗凝血酶（AT），是一种由肝脏合成的糖蛋白，属于丝氨酸蛋白酶抑制蛋白家族。除肝脏外，肺、肾、心、脾、肠、脑等器官也能合成AT。AT存在两种形式：α-AT（占90%）和β-AT（占10%）。     AT的功能机制 AT通过其反应中心环与靶蛋白酶的丝氨酸活性位点形成稳定复合物，从而不可逆地抑制凝血因子Ⅸa、Ⅹa、Ⅺa、Ⅻa以及Ⅶa与组织因子形成的复合体。这种抑制作用使其具有显著的抗血栓功能

Antithrombin

in plasma were reported, leading to the classification of antithrombin in a range from I to IV. It was subsequently shown that these various antithrombin activities were the function of one molecule, antithrombin III, whose name was reduced to antithrombin

Antithrombotic Effects of Naturally Derived Products on Coagulation and Platelet Function

properties); fucus (heparin-like activity); danshen (antithrombin III-like activity and anticoagulant bioavailability); and St. John’s Wort and American Ginseng (interference with drug metabolism). Other supplements, such as high doses of vitamin E (vitamin K