- 询价
- Cell Signaling Technology
- 3027
- USA
- 2026年01月30日
- W, IP, IHC-P
- Rabbit
- H,M,R,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
IGF-I Receptor β Antibody
- 抗原：
synthetic peptide corresponding to the carboxy-terminal residues of human IGF-IR beta
- 应用范围：
W, IP, IHC-P
- 宿主：
Rabbit
- 库存：
大量
- 保质期：
详见说明书
- 供应商：
CST
- 级别：
详见MSDS文件
- 适应物种：
H,M,R,Mk
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/300 ul (30 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | 300 ul (30 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IHC-P | H M R Mk | Endogenous | 95 | Rabbit |
| Protocols | |
|---|---|
| Specificity / Sensitivity | IGF-I Receptor beta Antibody detects endogenous levels of IGF-IR beta. It does not cross-react with insulin receptor. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal residues of human IGF-IR beta. Antibodies are purified by protein A andd peptide affinity chromatography. Western Blotting
Western blot analysis of various cell extracts using IGF-I Receptor beta antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human breast tumor section showing membrane and cytoplasmic staining, using IGF-I Receptor b Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using IGF-I Receptor b Antibody. |
| Background | Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8).
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验乙 -受体（β -受体） β -receptor 儿茶酚胺的受体之一。一般呈抑制反应，即一旦接受儿茶酚胺的作用，便产生血管、子宫、支气管等器管的舒张和心肌兴奋。由异丙基肾上腺素（ isopr-oterenol）的作用也可产生这种反应。而 3， 4-二氯异丙基肾上腺素（ DCI）、心得安等β -受体阻断剂可阻断其作用。
为儿茶酚胺受体之一。一般为抑制的反应，儿茶酚胺与β受体作用可引起血管、子宫和支气管肌等弛缓和心脏兴奋。异丙基肾上腺素也可使之产生效应。3，4-二氯异丙基肾上腺素（DCI）和萘异丙仲胺等β巡断剂可阻抑其作用。
Assays for GH, IGF-I, and IGF Binding Protein-3
The growth hormone/insulin-like growth factor (GH/IGF) axis is widely investigated in disorders of growth, development, and anterior pituitary function. Methods are described for three hormones in this axis (growth hormone, IGF-I, and IGF
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