- 询价
- Cell Signaling Technology
- 5196
- USA
- 2025年07月14日
- W, IP, IHC-P
- Rabbit
- H,M,R,Mk
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- 详细信息
- 技术资料
- 抗体英文名：
NDRG1 Antibody
- 抗原：
synthetic peptide corresponding to residues in the carboxy terminus of human NDRG1 protein
- 应用范围：
W, IP, IHC-P
- 宿主：
Rabbit
- 库存：
大量
- 保质期：
详见说明书
- 供应商：
CST
- 适应物种：
H,M,R,Mk
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IHC-P | H M R Mk | Endogenous | 46, 48 | Rabbit |
| Protocols | |
|---|---|
| Specificity / Sensitivity | NDRG1 Antibody detects endogenous levels of total NDRG1 protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues in the carboxy terminus of human NDRG1 protein. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from various cell lines using NDRG1 Antibody. Western Blotting
Western blot analysis of extracts from HeLa cells, mock transfected or transfected with SignalSilence® NDRG1 siRNA II #6257, using NDRG1 Antibody (upper) or β-Tubulin (9F3) Rabbit mAb #2128 (lower). IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using NDRG1 Antibody. IHC-P (paraffin)
Immunohistochemical analysis on SignalSlide® Phospho-Akt (Ser473) IHC Controls #8101 [paraffin-embedded LNCaP cell pellets, control (left) or LY294002-treated (right)] using NDRG1 Antibody (top) or Phospho-NDRG1 (Thr346) (D98G11) XP® Rabbit mAb #5482 (bottom). IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using NDRG1 Antibody. |
| Background | N-myc downstream-regulated gene 1 (NDRG1), also termed Cap43, Drg1, RTP/rit42, and Proxy-1, is a member of the NDRG family, which is composed of four members (NDRG1-4) that function in growth, differentiation, and cell survival (1-5). NDRG1 is ubiquitously expressed and highly responsive to a variety of stress signals including DNA damage (4), hypoxia (5), and elevated levels of nickel and calcium (2). Expression of NDRG1 is elevated in N-myc defective mice and is negatively regulated by N- and c-myc (1,6). During DNA damage, NDRG1 is induced in a p53-dependent fashion and is necessary for p53-mediated apoptosis (4,7). Research studies have shown that NDRG1 may also play a role in cancer progression by promoting differentiation, inhibiting growth, and modulating metastasis and angiogenesis (3,4,6,8,9). Nonsense mutation of the NDRG1 gene has been shown to cause hereditary motor and sensory neuropathy-Lom (HMSNL), which is supported by studies demonstrating the role of NDRG1 in maintaining myelin sheaths and axonal survival (10,11). NDRG1 is up-regulated during mast cell maturation and its deletion leads to attenuated allergic responses (12). Both NDRG1 and NDRG2 are substrates of SGK1, although the precise physiological role of SGK1-mediated phosphorylation is not known (13). NDRG1 is phosphorylated by SGK1 at Thr328, Ser330, Thr346, Thr356, and Thr366. Phosphorylation by SGK1 primes NDRG1 for phosphorylation by GSK-3.
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| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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