- 询价
- Cell Signaling Technology
- 3402
- USA
- 2025年07月14日
- W, IP, IF-F
- Rabbit
- H,M,R,Mk,C
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- 详细信息
- 技术资料
- 抗体英文名：
Myosin Va Antibody
- 抗原：
synthetic peptide corresponding to residues near the carboxy terminus of human myosin Va
- 应用范围：
W, IP, IF-F
- 宿主：
Rabbit
- 供应商：
CST
- 保质期：
详见说明书
- 适应物种：
H,M,R,Mk,C
- 库存：
大量
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IF-F=Immunofluorescence (Frozen)
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey C=Chicken
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IF-F | H M R (Mk) (C) | Endogenous | 207 | Rabbit |
| Protocols | |
|---|---|
| Specificity / Sensitivity | Myosin Va Antibody detects endogenous levels of total myosin Va heavy chain. Based on sequence homology, the antibody is expected to detect all known myosin Va splice variants. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human myosin Va. Western Blotting
Western blot analysis of extracts from SK-MEL-28 and C2C12 cells using Myosin Va Antibody. IF-F
Confocal immunofluorescent analysis of the hippocampus (left) and pons region (right) of adult rat brain using Myosin Va Antibody (green). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye). |
| Background | Myosin Va is a molecular motor protein involved in the transport of organelles, vesicles and other cellular cargo along actin filaments (reviewed in 1). The molecule consists of two identical heavy chains, which dimerize via helical domains in a coiled coil structure. The amino-terminal motor domains of the heavy chains contain both the ATPase and the actin-binding activities of myosin Va. The globular tail domains act in a regulatory capacity, binding the myosin Va cargo (2) or inhibiting motor activity by binding the head domains and preventing ATP consumption (3). Mutation of the murine dilute gene, which encodes myosin Va, causes defects in coat pigmentation as well as severe neurological defects (4). In melanocytes, the coiled coil structure of myosin Va is important in regulating the trafficking of melanosomes in conjunction with melanophilin and Rab27a (5). Myosin Va regulates trafficking and exocytosis of secretory granules in neuroendocrine cells (reviewed in 6) as well as RNA transport and distribution (7).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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