- 询价
- Cell Signaling Technology
- 2295
- USA
- 2025年08月31日
- W, IF-IC
- Rabbit
- H,M,R
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
C/EBPα Antibody
- 抗原：
synthetic peptide corresponding to the sequence of humanC/EBPα
- 应用范围：
W, IF-IC
- 宿主：
Rabbit
- 适应物种：
H,M,R
- 供应商：
CST
- 保质期：
详见说明书
- 库存：
大量
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IF-IC | H M R | Endogenous | 42, 28 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | C/EBPα Antibody detects endogenous levels of total C/EBPα protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of humanC/EBPα. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from THP1 and NIH/3T3-L1 cells using C/EBPα Antibody. IF-IC
Confocal immunofluorescent image of 3T3-L1 cells labeled with C/EBPalpha Antibody (green) showing nuclear localization in differentiated cells. |
| Background | CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcription factors that are critical for cellular differentiation, terminal function, and inflammatory response (1). Six members of the family have been characterized (C/EBPα, β, δ, γ, ε, and ζ) and are distributed in a variety of tissues (1). Translation from alternative start codons results in two isoforms of C/EBPα (p42 and p30), which are both strong transcriptional activators (2). It has been reported that insulin and insulin-like growth factor-I stimulate the dephosphorylation of C/EBPα, which may play a key role in insulin-induced repression of GLUT4 transcription (3). Phosphorylation of C/EBPα at Thr222, Thr226, and Ser230 by GSK-3 seems to be required for adipogenesis (4). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
Twenty-five years ago, Georges K�hler and C�sar Milstein invented a means of cloning individual antibodies, thus opening up the way for tremendous advances in the fields of cell biology and clinical diagnostics ( 1 ). However, in spite
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
inhibitors, and aliquot it for use. Then freeze the aliquots and keep just one around for day to day use at four degrees C. Raw serum containing antibodies: Aliquot into reasonable aliquots (usually 10-50 ml) appropriate to your use of the antibody
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