- 询价
- R&D
- 美国/中国
- xy-562C
- 2025年07月09日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- GABAA Receptor α2 Subunit Polyclonal Antibody详细信息：
-
Description A Receptor α2 Subunit Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Polyclonal Antibody GABAA Receptor α2-Subunit Form 
Antiserum Host Rabbit Species Reactivity Rat. Bovine, human, mouse, and rat have 100% amino acid sequence identity with the antigen used to raise the antibody. Specificity A Receptor α2 Subunit Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> GABAA Receptor α2 Subunit Polyclonal AntibodyGamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α and β subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α subunits of the receptor. Lastly, phosphorylation of β subunits of the receptor has been shown to modulate GABAA-R function.
This antibody was developed against a peptide representing the sequence that is specific for the α2 subunit of the receptor. It recognizes the 53kD GABAA-R α2 subunit in Western blots of rat brain membranes. The peptide antigen has no homology with any other GABAA-R subunit.Uses A Receptor α2 Subunit Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> This antibody is effective in immunoblotting; other applications not yet determined. Suggested Working Dilution A Receptor α2 Subunit Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> GABAA Receptor α2 Subunit Polyclonal AntibodyThe optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:1,000*
- Dot blot: 1:1,000
Notes A Receptor α2 Subunit Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> *Predicted MW = 53kD Storage A Receptor α2 Subunit Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Long term storage should be at -80°C. This shelf-life of this product is approximately 1 year.
References Kittler JT, McAinsh K, Moss SJ. Mechanisms of GABA A receptor assembly and trafficking - Implications for the modulation of inhibitory neurotransmission. Mol. Neurobiol. 26:2251 - 268, 2002.
Whiting PJ, McKernan RM, Wafford KA. Structure and pharmacology of vertebrate, GABAA receptor subtypes. In: International Review of Neurobiology (Bradley RJ, Harris RA, eds.), pp 95, San Diego: Academic Press, 1995.
Olsen RW, Tobin AJ. Molecular biology of GABAA receptors. FASEB 4:1469 - 1480, 1990.
Pritchett DB, Sontheimer H, Shivers BD, Yner S, Kettenman H, Schofield PR, Seeburg PH. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.Nature (London) 338:582-585, 1989.
Blair LAC, Levitan ES, Marshall J, Dionne VE, Barnard EA. Single subunits of the GABAA receptor form ion channels with properties of the native receptor. Science 242:577-579, 1988.Warranty/Conditions A Receptor α2 Subunit Polyclonal Antibody - NEUROSCIENCE" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Covance products may not be resold or modified for resale without prior written approval. - GABAA Receptor α2 Subunit Polyclonal Antibody
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xy-1179xy CTLA-4/CD152淋巴细胞相关抗原4/细胞毒性T细胞抗原-4
xy-0799xy CTn1 (cardiac troponin 1)心肌肌钙蛋白
xy-1376xy Cx32(Connexin-32)间隙连接蛋白32抗原
xy-1266xy CX36 (Connexin-36)间隙连接蛋白36抗原
xy-1050xy Cx40 (Connexin-40)间隙连接蛋白40(多肽)
xy-0811xy cx3cl1(chemokine (C-X3-C motif) ligand 1)趋化因子(C-X3-C 基元)配体1抗原
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xy-0572xy Cyclin B1周期素B1抗原
xy-1148xy Cyclin D2周期素D2抗原
xy-0660xy Cyclin D3(C-term)周期素D3抗原
xy-1742xy CYP3A4(Cytochrome p450 3A4)细胞色素P450 3A4抗原
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xy-1746xy DRD4 receptor peptide多巴胺受体-D4抗原
xy-1747xy DRD5 receptor(dopamine D5 receptor)多巴胺受体-D5抗原
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xy-0592xy DCC (Deleted in colorectal cancer gene)结直肠癌缺失基因抗原
xy-1269xy DCX(Doublecortin)双皮质素抗原
xy-2599xy DDB2(DNA damage-binding protein 2)损伤DNA结合蛋白2抗原
xy-1163xy Defensin Beta1防御素β1抗原
xy-2165xy Defensin Beta1(human)防御素β1抗原(人)
xy-1295xy Defensin Beta2/beta-defensin 2/BD-2(mouse)防御素β2抗原（小鼠）
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GABAA Receptor α2 Subunit Polyclonal Antibody
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