- 询价
- R&D
- 美国/中国
- xy-318P
- 2025年07月16日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- Sodium Calcium Exchanger 1 Monoclonal Antibody保存于运输说明：
- Store at -20°C
- 详细信息：
-
Description 
Monoclonal Antibody against Sodium Calcium Exchanger 1 NaCX-1 Clone 6H2 Form Lyophilized Purified Antibody Host Mouse Species Reactivity Broad tissue and species reactivity IsoType IgG2B [Ab] Sodium Calcium Exchanger 1 Monoclonal Antibody100 ug Specificity Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX1, NaCX2, and NaCX3), and two in the NaCKX family (NaCKX1 and NaCKX2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling.
6H2 was generated against a fusion protein from N-terminus of rabbit renal Na/Ca exchanger. It was subsequently purified via a protein G affinity column.Uses This antibody is effective in immunoblotting with strong and specific immunolabeling of the Na/Ca exchanger NaCX-1 (Mr ~120k and 160k) with a broad tissue and species reactivity.. Suggested Working Dilution The antibody should be reconstituted in 100 uL phosphate buffered saline (PBS: 137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use.
The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval.- Western blot: 1:1,000*
- Dot blot: 1:1,000
Notes Sodium Calcium Exchanger 1 Monoclonal AntibodyPredicted MW = 120 & 160 kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. References White KE, Gesek FA, Reilly RF, Friedman PA. NaCX1 Na/Ca exchanger inhibition by antisense oligonucleotides in mouse distal convoluted tubule cells. Kidney Int. 54:897-906, 1998.
Matsuoka S, Nicoll DA, Reilly RF, Hilgemann DW, Philipson KD. Initial localization of regulatory regions of the cardiac sarcolemmal Na+-Ca2+ exchanger. Proc Natl. Acad. Sci. U.S.A. 90:3870-3874, 1993.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Sodium Calcium Exchanger 1 Monoclonal Antibody
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xy-0358G-xyy5 Goat Anti-Guinea pig IgG/Cy5Cy5标记的羊抗豚鼠IgG
xy-0358G-xyy5.5 Goat Anti-Guinea pig IgG/Cy5.5Cy5.5标记的羊抗豚鼠IgG
xy-0358G-xyy7 Goat Anti-Guinea pig IgG/Cy7Cy7标记的羊抗豚鼠IgG
xy-0358G-xyE Goat Anti-Guinea pig IgG/PEPE标记的羊抗豚鼠IgG
xy-0358G-xyE-xyy3 Goat Anti-Guinea pig IgG/PE-Cy3PE-Cy3标记的羊抗豚鼠IgG
xy-0358G-xyE-xyY5 Goat Anti-Guinea pig IgG/PE-CY5PE-CY5标记的羊抗豚鼠IgG
xy-0358G-Axyxy Goat Anti-Guinea pig IgG/APCAPC标记的羊抗豚鼠IgG
xy-0358G-AF350 Goat Anti-Guinea pig IgG/Alexa Fluor 350Alexa Fluor 350标记的羊抗豚鼠IgG
xy-0358G-AF488 Goat Anti-Guinea pig IgG/Alexa Fluor 488Alexa Fluor 488标记的羊抗豚鼠IgG
xy-0358G-AF555 Goat Anti-Guinea pig IgG/Alexa Fluor 555Alexa Fluor 555标记的羊抗豚鼠IgG
xy-0358G-AF647 Goat Anti-Guinea pig IgG/Alexa Fluor 647Alexa Fluor 647标记的羊抗豚鼠IgG
xy-0358G-xyE-xyy5.5 Goat Anti-Guinea pig IgG/PE-Cy5.5PE-Cy5.5标记的羊抗豚鼠IgG
xy-0358G-xyE-xyy7 Goat Anti-Guinea pig IgG/PE-Cy7PE-Cy7标记的羊抗豚鼠IgG
xy-0358G-RBITxy Goat Anti-Guinea pig IgG/RBITC罗丹明标记的羊抗豚鼠IgG
xy-0358G-FITxy Goat Anti-Guinea pig IgG/FITCFITC标记的羊抗豚鼠IgG
xy-0358G-Golxy Goat Anti-Guinea pig IgG/Gold胶体金标记的羊抗豚鼠IgG
xy-0358G-Axy Goat Anti-Guinea pig IgG/AP碱性磷酸酶（AP）标记的羊抗豚鼠IgG
xy-0295G-Axy Goat Anti-rabbit IgG/AP碱性磷酸酶（AP）标记的羊抗兔IgG
xy-0295G-FITxy Goat Anti-rabbit IgG/FITCFITC标记的羊抗兔IgG
xy-0295G-xyy7 Goat Anti-rabbit IgG/Cy7Cy7标记的羊抗兔IgG
xy-0295G-xyE-xyY5 Goat Anti-rabbit IgG/PE-CY5PE-CY5标记的羊抗兔IgG
xy-0295G-xyE-xyy5.5 Goat Anti-rabbit IgG/PE-Cy5.5PE-Cy5.5标记的羊抗兔IgG
xy-0295G-xyE-xyy7 Goat Anti-rabbit IgG/PE-Cy7PE-Cy7标记的羊抗兔IgG
xy-0310G-Bio Goat Anti-Chicken IgG/Bio生物素标记的羊抗鸡IgG
xy-0310G-AF555 Goat Anti-Chicken IgG/Alexa Fluor 555Alexa Fluor 555标记的羊抗鸡IgG
xy-0310G-xyE-xyy5.5 Goat Anti-Chicken IgG/PE-Cy5.5PE-Cy5.5标记的羊抗鸡IgG
xy-0310G-xyE-xyy7 Goat Anti-Chicken IgG/PE-Cy7PE-Cy7标记的羊抗鸡IgG
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文献和实验相关实验
【翻译】Development trends for monoclonal antibody cancer therapeutics
). However, since 2000, humanized and human mAbs have been entering clinical study at approximately the same rate (4.3 versus 4.5 mAbs per year, respectively). Figure 1 | Categories of monoclonal antibody cancer therapeutics entering clinical study during 1980–1989
of cell injury. The mechanism for this is related to the fact that activation of the exchanger is closely coupled to sodium influx and, therefore, to elevation in intracellular calcium concentrations through the Na−Ca exchange. The NHE is exquisitely
Western Blotting with Monoclonal Ant
the blocking buffer from the blot, add the antibody solution, and incubate with agitation for 30 minutes at 37˚C, one hour at room temperature, or overnight at 4˚C. Enzyme conjugated secondary antibody Note: The inclusion of sodium azide is to be avoided
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Sodium Calcium Exchanger 1 Monoclonal Antibody
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