丝裂原活化蛋白激酶磷酸酶-1抗体

丝裂原活化蛋白激酶磷酸酶-1抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

丝裂原活化蛋白激酶磷酸酶-1抗体产品说明

MKPs是一类丝氨酸/苏氨酸和酪氨酸双重底物特异性的磷酸酶 ,对于丝裂素活化蛋白激酶活性的调节起着十分重要的作用，可使丝裂素活化蛋白激酶上的苏氨酸/酪氨酸去磷酸化失活。目前研究发现MKPs分别有MKP-1、MKP-2、MKP-3及MKP4-6。
MKPs受MAPK信号通路中多种成分的诱导 ,决定了它与MAPK之间作用的特异性。 通过去磷酸化作用调节MAPK信号途径的活性 ,确保了细胞内信号的精确传递 ,参与了多种主要的细胞功能的调节。
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.xy-5822R H Cadherin心脏钙粘蛋白抗体
xy-6592R HSD17B617-β-羟脱氢酶6抗体
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xy-5889R Hyaluronidase3透明质酸酶2/玻璃酸酶2抗体
xy-6538R HOXB2同源盒蛋白B2抗体
xy-6539R HOXB8同源盒蛋白B8抗体
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xy-3782R Acetyl-Histone H2B(K5)乙酰化组蛋白H2B抗体
xy-3783R Acetyl-Histone H2B(K20)乙酰化组蛋白H2B抗体
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xy-5364R phospho-HSF1(Ser307)磷酸化热休克因子1抗体
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xy-3828R HNF4A肝细胞核因子4α抗体
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丝裂原活化蛋白激酶磷酸酶-1抗体