- 询价
- R&D
- 美国/中国
- xy-39220
- 2025年07月13日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Purified (SIGNET)保存于运输说明：
- Store at -20°C or below.
- 详细信息：
-
Description Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Beta Amyloid (Aβ) Monoclonal Antibody, 4G8
(Formerly Signet Catalog Nos.: 9200-02, 9200-05, 9200-10)
Covance is the Exclusive Provider of this Antibody ProductIntended Use 
**Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 4G8 Form Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Purified (SIGNET)Ascites Fluid Host Mouse Species Reactivity Human, Mouse IsoType IgG2b [Ab] Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> ~2 mg/mL Specificity Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> This antibody is reactive to amino acid residues 17-24 of beta amyloid. The epitope lies within amino acids 18-22 of beta Amyloid (VFFAE). Beta amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Signet’s beta Amyloid antibody 4G8 reacts to the abnormally processed isoforms, as well as precursor forms. Uses Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> This antibody is effective in immunoblotting, immunohistochemistry (IHC), immunoprecipitation (IP) immunoaffinity purifications and ELISA. Suggested Working Dilution Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Purified (SIGNET)The optimal working dilution should be determined for each specific assay condition. - IHC: 1:100 - 1:1,000
Tissue Sections: Formalin-fixed human and animal paraffin-embedded brain sections
Pretreatment: Formic acid (70%) for 10-30 minutes at room temperature
- ELISA: 1:1,000 - 1:10,000
Storage Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. References Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA Feb 25, 2009.
Kimura N, et al. Age-related changes of intracellular Abeta in cynomolgus monkey brains. Neuropath Appl Neurobiol 31(2):170-80, 2005.
Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005.
Iijima K, et al. Dissecting pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer’s disease. PNAS 101(17):6623-6628, 2004.
Li M, et al. Macrophage colony stimulatory factor and interferon-gamma trigger distinct mechanisms for augmentation of beta-amyloid-induced microgliamediated neurotoxicity. J Neurochem 91:623-33, 2004.
Poduloso JF, et al. Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer’s disease amyloid plaques. Biochem 43:6064-6075, 2004.
Venezia V, et al. Apoptotic cell death influences the signaling activity of the amyloid precursor protein through SchA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells. J Neurochem 90:1359-1370, 2004.
Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci Res Comm 2:121-130, 1988.
Kim KS, et al. Neurosci Res Comm 7:113, 1988.Warranty/Conditions Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Covance products may not be resold or modified for resale without prior written approval. - IHC: 1:100 - 1:1,000
- Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Purified (SIGNET)
- xy-6173R Rab11ras癌基因家族Rab11蛋白抗体
xy-6182R RBP4视黄醇结合蛋白4抗体
xy-6183R REG1A胰岛细胞再生因子ICRF抗体
xy-6184R Renin肾素/血管紧张素形成酶Ren1抗体
xy-6185R RSPO1分泌性蛋白RSPO1抗体
xy-6171R RASA2RAS的GTP酶激活蛋白抗体
xy-6153R RAC2G蛋白P21 RAC2抗体
xy-6154R RAC1+RAC2GTP结合蛋白RAC1+RAC2抗体
xy-6176R RAB8ras癌基因家族Rab8蛋白/原癌基因c MEL抗体
xy-6174R RAB2ras癌基因家族Rab2抗体
xy-6179R RAB3Aras癌基因家族Rab3a抗体
xy-6177R RAB9ras癌基因家族Rab9蛋白抗体
xy-6178R RAB20ras癌基因家族RAB20抗体
xy-6170R RALA+RALBRas样蛋白A+B抗体
xy-10145R Rad51Rad51抗体
xy-12290R RBMY1FRNA结合蛋白片段Y染色体家族蛋白2抗体
xy-12289R RBMY1A1RNA结合蛋白片段Y染色体家族蛋白1抗体
xy-6358R RNA polymerase IIIRNA聚合酶III抗体
xy-10118R phospho-Ron (Tyr1238+Tyr1239)磷酸化原癌基因c-Met相关酪氨酸激酶抗体
xy-12294R phospho-RUNX1(Ser303)磷酸化急性髓细胞白血病1蛋白抗体
xy-7121R Rad23DNA修复蛋白Rad23抗体
xy-12261R RTF1组织相容性复合物RTF1抗体
xy-1574R RRM1核糖核苷酸还原酶1抗体
xy-9232R RNF167环指蛋白167抗体
xy-2214R Resistin抵抗素抗体
xy-3560R RASGRF1Ras特异性鸟嘌呤核苷酸释放因子1
xy-3554R Rsk2核糖体S6激酶RSK2抗体
xy-3647R RACK1受体激活蛋白激酶C1抗体
xy-3863R ROR Gamma孤儿核受体抗体
xy-9163R RNF17环指蛋白17抗体
xy-1264R RSV呼吸道合胞病毒抗体
xy-4179R RAD9细胞周期检查控制蛋白质抗体
xy-5642R phospho-RAD9(Ser272)磷酸化细胞周期检查控制蛋白质抗体
xy-5655R phospho-RAD9(Ser336)磷酸化细胞周期检查控制蛋白质抗体
xy-5656R phospho-RAD9(Ser375)磷酸化细胞周期检查控制蛋白质抗体
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Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Purified (SIGNET)
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