- 询价
- R&D
- 美国/中国
- xy-39760
- 2025年07月15日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- ERAB (10D12) Monoclonal Antibody (SIGNET)保存于运输说明：
- Store at -20°C or below
- 详细信息：
-
Description 
Monoclonal Antibody against Endoplasmic Reticulum Amyloid Beta Binding Protein (ERAB)
(Formerly Signet Catalog Nos: 9760-02, 9760-05, 9760-10)Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 10D12 Form ERAB (10D12) Monoclonal Antibody (SIGNET)Tissue Culture Supernatant (in PBS; no preservatives or carrier proteins) Host Mouse Species Reactivity Human IsoType IgG2b/kappa [Ab] 1 mg/mL Specificity Signet’s ERAB antibody, Clone 10D12, is specific for the recombinant human ERAB protein (27kDa). ERAB is also known as HSD-10 and ABAD. The clone 10D12 recognizes the endogenous ERAB protein in extracts from cells with virtually no cross-reactivity to other human proteins in immunoblots and ELISA assays. Cross-reactivity to mouse or other species has not been tested. The clone 10D12’s epitope has been mapped to amino acids 61-67 (APSTRVS).
ERAB has been associated with amyloid beta neurotoxicity. ERAB is an intracellular 27kDa polypeptide which appears to be up regulated in the brains of Alzheimer’s disease patients.
This antibody was generated against recombinant, full-length human ERAB protein.Uses ERAB (10D12) Monoclonal Antibody (SIGNET)This antibody is effective in immunoblotting, immunohistochemistry (IHC) and ELISA. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. Storage Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. References He XY, et al. Function of human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase in androgen metabolism. Biochim BioPhys Acta 1484 (2-3):267-77, 2000.
Yan SD, et al. Role of ERAB/L-3-hydroxy-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity. J Biol Chem 274(4):2145-56, 1999.
Oppermann UC, et al. Binding of amyloid beta peptide to mitochondrial CoA dehydrogenase (ERAB): regulation of a SDR enzyme activity with implications for apoptosis in Alzheimer’s disease. FEBS Lett 451(3):238-42, 1999.
Sambamurti K, Lahiri DK. ERAB contains a putative noncleavable signal peptide.Biochem Biophys Res Commun 249(2):546-9, 1998.
Yan SD, et al. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer’s disease. Nature 389(6652):689-95, 1997.
Furuta S, et al. Cloning and expression of cDNA for a newly identified isozyme of bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into mitochondria.Biochim BioPhys Acta 1350(3):317-24, 1997.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - ERAB (10D12) Monoclonal Antibody (SIGNET)
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ERAB (10D12) Monoclonal Antibody (SIGNET)
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