- 询价
- ATCC
- 美国/中国
- xy-04-0015
- 2025年07月12日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Stemolecule ALK5 Inhibitor
- 库存：
1
- 供应商：
上海信裕
- Stemolecule ALK5 Inhibitor保存于运输说明：
- Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C
- 详细信息：
-
Stemolecule™ ALK5 Inhibitor
Stemolecule™ ALK5 Inhibitor is a selective and ATP-competitive inhibitor of a TGF-β family type I receptor, activin receptor-like kinase (ALK5)1. Inhibition of TGF-β signaling increased the efficiency of reprogramming of rat liver progenitor cells and IMR90 human fibroblast cells to mouse embryonic stem (ES) cell-like induced pluripotent stem (iPS) cells, as well as maintained these cells in an undifferentiated state for over 30 passages2. The mouse ES cell culture condition together with inactivation of TGF-β signaling provided a robust culturing method of reprogrammed rat and human iPS cells2. This study indicates the significant role of TGF-β signaling in regulating ES cell fate determination, and provides a novel method for culture of rat and human iPS cells.
Stemolecule ALK5 Inhibitor产品参数
Alternate Name 2-(3-(6-methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine Chemical Formula C17H13N5 Structure Molecular Weight 287.32 CAS Number NA Purity >99% Formulation Yellow solid Solubility Stemolecule ALK5 Inhibitor Soluble in DMSO (100 mM) or methanol (17 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 384 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%. Storage Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C Stability Stock solutions stable at -20°C for 6 months Quality Control The purity of Stemolecule ALK5 Inhibitor was determined by HPLC analysis. The accurate mass and structure of Stemolecule ALK5 Inhibitor was determined by mass spectrometry and NMR, respectively. Cellular toxicity of ALK5 Inhibitor was tested on HeLa and HEK293 cells. References - Gellibert, F., Woolven, J., Fouchet, M. H., Mathews, N., Goodland, H., Lovegrove, V., Laroze, A., Nguyen, V. L., Sautet, S., Wang, R., Janson, C., Smith, W., Krysa, G., Boullay, V., De Gouville, A. C., Huet, S., and Hartley, D. (2004) Identification of 1, 5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem 47, 4494-506.
- Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., Hao, E., Hayek, A., Deng, H., and Ding, S. (2008) Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors. Cell Stem Cell 4, 16-19.
- Stemolecule ALK5 Inhibitor
- xy-2173xy OLFM1 peptide嗅球蛋白1多肽抗原
xy-1181xy ORX-A(orexin-A)增食欲素-A/欲激素A抗原
xy-1314xy OTR(oxytocin receptor)缩宫素受体
xy-1095xy OXR (Orexin receptor)食欲素受体(多肽)
xy-1483xy P2P-R/RBBP6(proliferation potential protein related)增殖潜能相关蛋白抗原
xy-0534xy P19ARFp19ARF抑癌基因抗原
xy-2210xy phospho-p38 ERK/MAPK14 (pThr180/pTyr182) peptide磷酸化丝裂原活化蛋白激酶p38抗原
xy-1689xy MKK3(MAP Kinase Kinase 3)丝裂原活化蛋白激酶MKK3/6抗原
xy-2090xy P53(wt-p53)肿瘤抑制基因抗原（野生型P53）
xy-0913xy Mtp53(Mutant type p53)突变型P53抗原
xy-0942xy WIG-1(wtp53-induced gene 1)野生型p53诱导基因1抗原
xy-1346xy P73 proteinP73肿瘤抑制基因抗原
xy-1426xy p70 S6 Kinase/P70 Beta1p70S6Kb抗原
xy-0588xy PALB2(partner and locaizer of BRCA2)乳腺癌易感基因相关蛋白2
xy-1478xy PAFR/PTAFR血小板活化因子受体抗原
xy-2270xy Phospho-PAK4 (Ser99) peptide磷酸化p21激活激酶4多肽抗原
xy-0655xy PAK7/PAK5/MBT激活激酶PAK7/PAK5抗原
xy-0828xy PAR-1 (Protease-activated receptors-1)蛋白酶激活受体-1抗原
xy-1178xy PAR-2 (Protease-activated receptors-2)蛋白酶激活受体-2抗原
xy-1196xy PAR4 (protease-activated receptor 4)蛋白酶活化受体4/前列腺细胞凋亡反应蛋白4抗原
xy-2138xy PARP(poly ADP-ribose polymerase)N-Terminus多腺苷二磷酸多聚酶抗原(N端)
xy-1201xy PAX8(Paired box gene 8)配对盒基因8抗原
xy-1102xy PAX9(Paired box gene 9)配对盒基因9抗原
xy-1159xy P-cadherin(placental)P-钙粘附分子抗原
xy-1617xy LI-cadherin(liver-intestine cadherin)肝肠钙粘连蛋白抗原
xy-1608xy PDCD4(programmed cell death 4)凋亡相关蛋白4抗原
xy-1333xy TFAR19(TF-1 cell apoptsis-related gene 19)凋亡相关蛋白TFAR19抗原
xy-2215xy PCNA(phosphos Dyr211)peptide磷酸化增殖细胞核多肽抗原
xy-1345xy PCX/PODXL(Podocalyxin)足细胞特异蛋白抗原
xy-1316xy PDGF-BB peptide血小板源性生长因子-BB抗原
xy-0923xy Pdx1(pancreatic and duodenal homeobox 1)胰十二指肠同源异型盒基因抗原
xy-2219xy pectinesterase inhibitor 18 peptide果胶酶抗原
xy-1084xy PEG10(Paternally expressed gene 10)肝癌高表达基因抗原
xy-2106xy PENK/Enkephalin A(Preproencephalin A)脑啡肽
xy-0584xy PEPT2 (Peptide-transporters 2)肠道肽转运蛋白2/小肽转运蛋白2抗原
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Generation of Novel Rat and Human Pluripotent Stem Cells by Reprogramming and Chemical Approaches
) have been generated from both mouse and human somatic cells by genetic transduction. We had successfully established novel rat iPSCs (riPSCs), which can be homogenously maintained by LIF and a cocktail of ALK5 inhibitor, GSK3 inhibitor and MEK inhibitor. riPSCs share
技术资料暂无技术资料 索取技术资料
