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- ATCC
- 美国/中国
- xy-04-0014
- 2025年07月10日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Stemolecule A83-01
- 库存：
1
- 供应商：
上海信裕
- Stemolecule A83-01保存于运输说明：
- Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C.
- 详细信息：
-
Stemolecule™ A83-01
A83-01是TGF-βI型受体ALK5, Activin/Nodal受体ALK4，nodal受体ALK7的选择性抑制剂。对ALK4, ALK5和ALK7的抑制性比SB431542更强，微弱抑制ALK1, ALK2, ALK3和ALK6。A 83-01通过抑制 Smad2磷酸化从而抑制TGF-β诱导上皮细胞转变成间充质干细胞。用于获得大鼠和人的ips细胞。
A83-01 is a selective inhibitor of the TGF-β type I receptor ALK5, the Activin/Nodal receptor ALK4, and the nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). This molecule is more potent than SB431542 in its inhibition of ALK4, 5, and 7, and only weakly inhibits ALK1, 2, 3, and 6. A 83-01 inhibits the TGF-β-induced epithelial-to-mesenchymal transition (EMT) via the inhibition of Smad2 phosphorylation1. This small molecule has been used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state2View Poster
Stemolecule A83-01产品参数
Alternate Name 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide Chemical Formula C25H19N5S Structure Molecular Weight 421.52 CAS Number 909910-43-6 Purity >98% Formulation Stemolecule A83-01 Pale yellow solid Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 475 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%. Storage Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C. Stability Stock solutions stable at -20°C for 6 months Quality Control The purity of A83-01 was determined by HPLC analysis. The accurate mass and structure of A83-01 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of A83-01 was tested on HeLa and HEK293 cells. References - Tojo, M., Hamashima, Y., Hanyu, A., Kajimoto, T., Saitoh, M., Miyazono, K., Node, M., and Imamura, T. (2005). The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci 96, 791-800.
- Li, Ding, 2008, Cell Stem Cell.
- Stemolecule A83-01
- xy-0903xy Natrexone/BSA:Natrexone/KLH纳曲酮偶联牛血清白蛋白：纳曲酮偶联血蓝蛋白
xy-1052xy NAP1 (nucleosome assembly protein 1)核小体组装蛋白1（多肽）
xy-1172xy N-cadherinN-钙粘附分子抗原
xy-1519xy E-cadherinE-钙粘附分子抗原
xy-0513xy Nephrin Protein去氧肾上腺素
xy-1055xy Neurocan神经粘蛋白抗原
xy-1366xy NF2/merlin(neurofibromatosis type 2)2型神经纤维瘤抗原
xy-1417xy NFATc1活化T细胞核因子1蛋白
xy-0982xy phospho-NFKB p65 (pSer536) peptide磷酸化细胞核因子/磷酸化k基因结合核因子抗原
xy-1194xy NF-KapBp50(p50 NF-kappa B;p50NFKB)细胞核因子50/κ基因结合核因子50抗原
xy-0922xy NGN3(neurogenin 3; Neurog3)神经元素3抗原
xy-1065xy NGX6 (nasopharyngeal carcinoma/NPC associated gene 6)鼻咽癌细胞相关基因6（多肽）
xy-2012xy NIT2 (nitrilase family, member 2)NIT2蛋白抗原
xy-0069xy NKA(Neurokinin A)神经激肽A抗原
xy-2411xy NKG2A/CD159a/KLRC1NK细胞受体2A/自然杀伤细胞活化性受体2A抗原
xy-0938xy NKG2D(natural killer cell group 2D)NK细胞受体/自然杀伤细胞活化性受体
xy-0688xy Nm23(NDP Kinase A,NDPKA)肿瘤转移抑制基因抗原
xy-1066xy Nm23-H1 (nucleoside dIPhosphatase kinase A)肿瘤抑制基因抗原
xy-1315xy Nogo-B/A轴索过度生长抑制因子-B/A抗原
xy-2072xy NOS-2 peptide一氧化氮合成酶-2多肽抗原
xy-1335xy Notch1/MOTC(Neurogenic locus notch homolog protein 1)跨膜受体蛋白Notch-1抗原
xy-1537xy NADPH peptide还原型辅酶Ⅱ抗原
xy-1069xy proCNP/NPPC (pro-natriuretic peptide)促尿钠排泄肽前体C抗原
xy-0937xy NPY2R(Neuropeptide Y Receptor Type 2)神经肽Y受体2（多肽）
xy-1070xy NPY1R (neuropeptide Y1 receptor)神经肽Y1受体抗原
xy-2184xy NQO1(NAD(P)H:quinone oxidoreductase l)醌氧化还原酶抗原
xy-1068xy NR1/NMDAR1(N-Methyl-d-Asprtate receptor 1)谷氨酸受体1（多肽）
xy-2030xy NR1/NMDAR1/GLUR1(N-Methyl-d-Asprtate receptor 1)谷氨酸受体1抗原
xy-2175xy NR1/NMDAR1谷氨酸受体1
xy-1067xy NR2C/NMDAR2C(N-Methyl-d-Asprtate receptor 2C)谷氨酸受体2C（多肽）
xy-1146xy N-ras原癌基因抗原
xy-1074xy Nrf2 peptide核因子2相关因子2抗原
xy-1342xy NRF-1(nuclear respiratory factor-1)核呼吸因子-1抗原
xy-1958xy NTCP(Na+/taurocholate Cotransporting Polypeptide)钠离子/牛磺胆酸共转运蛋白抗原
xy-1375xy Ghrelin 28脑肠肽28
xy-1495xy OCLN(Occluding)咬合蛋白抗原
xy-1111xy Oct-4(Octamer-4)胚胎干细胞关键蛋白抗原
xy-1294xy ODC(Ornithine decarboxylase)鸟氨酸脱羧酶抗原
xy-2086xy ompF(putative outer membrane porin F protein)小肠结肠炎耶尔森氏菌膜通道蛋白抗原
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文献和实验CD83 分子 CD83 常用单克隆抗体或代号： HB15 主要表达细胞： Ba,Ta,DC,LHC [B] 分子质量(kDa)和结构： gp43(IgSF) 功 能： 参与APC功能和细胞间相互作用? CD83 Summary: Marker for dendritic cells May assist in antigen presentation or cellular
流式细胞术应用场景
实验83 植物的向性运动（示范） 原理 植物在受到某种刺激，如果各方向来的刺激强度不均一时，就会产生运动，植物的向光性和向地性，就是容易被观察到的向性运动。运动的方向与刺激方向有关，向着刺激方向运动即为正向性，背着刺激方向运动即为负向性。 仪器药品 温箱 锡纸 光照箱 暗室 培养皿 灯光
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