- 询价
- ATCC
- 美国/中国
- xy-04-0010
- 2025年07月15日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Stemolecule SB431542
- 库存：
1
- 供应商：
上海信裕
- Stemolecule SB431542保存于运输说明：
- 4°C protected from light. Following reconstitution, store aliquots at -20°C
- 详细信息：
-
Stemolecule™ SB431542
Stemolecule™ SB431542是活化受体激酶的抑制剂。是ALK-4, -5 ，-7的潜在抑制剂，SB431542抑制内在的活化剂以及TGF-β信号，而不影响应用ALK-1, -2, -3, -6的BMP信号。据报道，1μM浓度的SB431542能刺激来源于胚胎干细胞的内胚层细胞的增殖，分化和形成
Stemolecule™ SB431542 is an inhibitor of the TGF-β1 activin receptor-like kinases (ALKs). It is a selective and potent inhibitor of ALK-4, -5 and -7. SB431542 inhibits endogenous activin and TGF-β signaling without affecting more divergent BMP signaling utilizing ALK-1, -2, -3, and -61, 2. Watabe and colleagues (2003) reported that at a concentration of 1μM, SB431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells3View Poster
Stemolecule SB431542产品参数
Chemical Formula C22H16N4O3 Alternate Name 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin- 2-yl-1H-imidazol-2-yl)-benzamide hydrate 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H- imidazol-2-yl]-benzamide hydrate 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)- 1H-imidazol-2-yl]-benzamide hydrate Structure Molecular Weight 384.4 CAS Number 301836-41-9 (anhydrous) PubChem Substance ID 24724609 Purity >98.3% by HPLC analysis Formulation Stemolecule SB431542 White solid Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 1301 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%. Storage 4°C protected from light. Following reconstitution, store aliquots at -20°C Stability Stock solutions stable at -20°C for 6 months Quality Control The purity of SB431542 was determined by HPLC analysis. The accurate mass and structure of SB431542 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of PD173074 was tested by using HeLa and HEK293 cells. References - Laping, N. J. et al., Mol. Pharmacol., 62:58-64 (2002).
- Inman, G. J. et al., Mol. Pharmacol., 62:65-74 (2002).
- Watabe T. et al., J. Cell Biol., 163(6):1303-1311 (2003).
- Tongxiang Lin, Rajesh Ambasudhan, Xu Yuan, Wenlin Li, Simon Hilcove, Ramzey Abujarour, Xiangyi Lin, Heung Sik Hahm, Ergeng Hao, Alberto Hayek & Sheng Ding. (2009) A chemical platform for improved induction of human iPSCs. Nat Meth 1393.
- Stemolecule SB431542
- xy-1430xy A/H1N1-M2 Human(Avian influenza Matrix Protein-2 Human)A型人流感病毒H1N1-M2蛋白多肽
xy-0422xy A/H1N1-M2 Swine(Avian influenza Matrix Protein-2 Swine)A型猪流感病毒H1N1-M2蛋白
xy-2001xy H1N1(Influenza A virus ,hemagglutinin)流感病毒A抗原
xy-2002xy H1N1(Influenza A virus ,hemagglutinin)流感病毒A抗原
xy-2560xy H2AX peptide组蛋白H2AX多肽抗原
xy-2003xy H1N1(Influenza A virus ,hemagglutinin)流感病毒A抗原
xy-2004xy H1N1(Influenza A virus ,hemagglutinin)流感病毒A抗原
xy-1235xy Haase(hyaluronidase)透明质酸酶/玻璃酸酶抗原
xy-0843xy HA tagHA tag标签多肽
xy-0966xy HA tag(map)HA tag标签（分支多肽）
xy-0540xy HAI-1(Hepatocyte Growth Factor Activator Inhibitor 1)肝细胞生长因子激活物抑制因子抗原
xy-0847xy HBA1(hemoglobin alpha 1)人类血红蛋白α1抗原
xy-2169xy VWCE/URG11(von Willebrand factor C and EGF domain-containing)乙型肝炎病毒X蛋白(HBxAg)抗原
xy-2171xy URGCP/URG4(Up-regulator of cell proliferation)乙型肝炎病毒X蛋白(HBxAg)抗原
xy-2172xy URGCP/URG4(Up-regulator of cell proliferation)C terminal肝炎病毒X蛋白(HBxAg)C端抗原
xy-1912xy Alpha-HCG(Human chorionic gonadotropin Alpha )人α亚基人绒毛膜促性腺激素多肽抗原
xy-1745xy HCFHrp/BTA(Bladdertumor antigen)human膀胱肿瘤抗原
xy-2155xy HER2 receptor(NT)(erbB-2 isoform 2 receptor N-Terminus)c-erbB-2受体抗体(N端)
xy-2156xy HER2 receptor(NT)(erbB-2 isoform 2 receptor N-Terminus)c-erbB-2受体抗原(N端)
xy-1025xy HGF(hepatocyte growth factor)肝细胞生长因子抗原
xy-0860xy HHV8/ORF50(Human herpesvirus 8 type P)人类疱疹病毒8抗原
xy-0859xy HHV8/ORF50(Human herpesvirus 8 type P)人类疱疹病毒8抗原
xy-0870xy HHV8/ORF K2(Human herpesvirus 8 type P)人类疱疹病毒8抗原
xy-1407xy HIF-1 Beta/ARNT1(Hypoxia-inducible factor-1 Beta)缺氧诱导因子1β 抗原
xy-1447xy HIF-2 Alpha (Hypoxia-inducible factor-2 Alpha)缺氧诱导因子2α 抗原
xy-0931xy Histone H1b(Histone H1.4)组蛋白H1b抗原
xy-1414xy HDAC1/HD1(histone deacetylase 1)组织蛋白去乙酰化酶1抗原
xy-0879xy Flag-Tag (CT)Flag Tag标签多肽
xy-0965xy DYKDDDDK Tag(CT)/Flag-Tag标签DYKDDDDK Tag分支肽
xy-2107xy T7 tag(recombinant T7-tagged proteins)T7 tag标签抗原
xy-2109xy V5 tag(recombinant V5-tagged protein)V5 tag多肽抗原
xy-2112xy KT3 tagKT3 tag标签抗原
xy-2110xy VSV-G tag(vesicular stomatitis virus glycoprotein)VSV-G tag标签抗原
xy-1198xy HLA-DR(human leukoyte Antigen DR)HLA-DR抗原
xy-1279xy HLA-E人类白细胞抗原E
xy-1030xy Anti-HMGA1 (high mobility group AT-hook 1)高迁移率族蛋白A1抗原 - Stemolecule SB431542
- xy-0556xy HMGA2 (high mobility group A2)高迁移率族蛋白A2抗原
xy-0827xy HO-1/HSP32 (Hemeo xygenase 1)血红素氧合酶-1/热休克蛋白-32抗原
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验【求助】SB-431542 这个阻断剂用于阻断大鼠TGF通路 剂量如何掌握? 谢谢
张华高伟忠520 :o) 一顿饭 你应该查查文献可以看到吧，老大？ 就算查到了，不同的实验室或许条件不一样，我还是建议你用比如用5uM,10uM,20uM,50uM,100uM做个梯度，然后用WB检测阻断情况。选择完全阻断最小的剂量做你后面的实验。因为剂量越大，非特异性阻断作用越强，而你得到的数据说服力越小。 如果需要可PM我，我有一些关于阻滞剂使用的文献，蛮不错。
joya58 想请教大虾们一个问题，我准备定p38mapk的磷酸化抑制剂，看有SB202190和SB203580两种，文献上都有用，但是不知道有什么区别，该如何选择？ 还有从哪家公司购买比较好？calbiochem? 丁香通 建议到丁香通发布求购信息 1、信息可持续保留，不会像bbs帖子这样容易沉下去 2、发布求购信息，有机会赢取千元大奖，每月都有中奖机会，详见： 你求购
世霸总批发 SB1A01 SB1A01S SB1A02 SB1A02S SB1A03 SB1A03S SB1A01E SB1A01ES
技术资料暂无技术资料 索取技术资料
