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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Stemolecule Y27632
- 库存：
1
- 供应商：
上海信裕
- Stemolecule Y27632保存于运输说明：
- Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C.
- 详细信息：
-
Stemolecule™ Y27632
Y27632 is a Rho-associated kinase ROCK inhibitor1. Y27632 has recently been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2. This inhibitor has also been shown to enhance survival during the transplantation of ES cell-derived neural precursors3. View Poster
Y27632是ROCK抑制剂。ROCK能阻止细胞凋亡，增强分离人胚胎干细胞的存活率和克隆效率，而不影响其自我更新的能力或细胞多能性。还能增强胚胎干细胞来源的神经细胞的抑制存活率。Stemolecule Y27632产品参数
Alternate Name (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridine-4-yl)cyclohexanecarboxamide dihydrochloride Chemical Formula C14H23Cl2N3O Structure Molecular Weight 320.3 CAS Number 146986-50-7 Purity >97.5% by HPLC analysis Formulation Stemolecule Y27632 White solid Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 182 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%. Storage Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C. Stability Stock solutions stable at -20°C for 6 months Quality Control The purity of Y27632 was determined by HPLC analysis. The accurate mass and structure of Y27632 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of Y27632 was tested by using HeLa and HEK293 cells. References - Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., and Narumiya, S. (2000). Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 57, 976-983.
- Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J. B., Nishikawa, S., Nishikawa, S., Muguruma, and K., Sasai, Y. (2007). A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol 25, 681-686.
- Koyanagi, M., Takahashi, J., Arakawa, Y., Doi, D., Fukuda, H., Hayashi, H., Narumiya, S., and Hashimoto, N. (2008). Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J. Neurosci Res 86, 270-280.
- Stemolecule Y27632
- xy-0542xy CDK1 (Cyclin-Dependent Kinase 1)周期素依赖性激酶1抗原
xy-0559xy CDK5(Cyclin Dependent Kinase 5)周期素依赖性激酶5抗原
xy-0568xy CDK6 (Cyclin Dependent Kinase 6)周期素依赖性激酶6抗原
xy-0569xy CDK7/Cyclin H/MAT1周期素依赖性激酶7抗原
xy-0570xy CDK8(Cyclin Dependent Kinase 8)周期素依赖性激酶8抗原
xy-0538xy Cdkn1c/p57/Kip2 (Cyclindependent kinase inhibitor 1C)周期蛋白依赖激酶抑制因子1C抗原
xy-1093xy CGP-39/YKL-40(Chitinase-3-like protein 1 )软骨糖蛋白39（多肽）
xy-2080xy Cecropin抗菌肽/天蚕素（多肽）
xy-2048xy HER2 receptor(erbB-2 isoform 2)c-erbB-2受体抗原
xy-1085xy C-erbB-4/HER4/erbB-4 (epidermal growth factor receptor4)c-erbB-4癌基因抗原
xy-1277xy CFTR(cystic fibrosis transmembrane conductance regulator)囊性纤维化跨膜转运调节因子抗原
xy-0775xy CG6856-PA peptideCG6856-PA抗原
xy-0539xy CGA(Chromogranin A)嗜铬粒素A抗原
xy-0543xy CGB(Chromogranin B)嗜铬粒素B抗原
xy-1150xy ChRM1(muscarinic acetylcholine receptor)毒蕈碱型乙酰胆碱受体M1抗原
xy-1289xy ChRM3 peptide毒蕈碱型乙酰胆碱受体M3抗原
xy-1059xy CK18(Cytokeratin 18)细胞角蛋白18(多肽)
xy-2043xy CK18 peptide细胞角蛋白18多肽抗原
xy-1339xy CK18(Cytokeratin 18)细胞角蛋白18抗原（C端）
xy-1792xy CK14/17/42/10 peptide细胞角蛋白14抗原
xy-1270xy CK16(Cytokeratin 16)细胞角蛋白16抗原
xy-1431xy CK17(Cytokeratin 17)细胞角蛋白17抗原
xy-1244xy CK1/8/19 (Cytokeratin1/8/19; Keratin 1/8/19)peptide细胞角蛋白1/8/19抗原
xy-1005xy CK2(casein kinase 2)细胞角蛋白2抗原
xy-1060xy CK5(Cytokeratin 5)细胞角蛋白5抗原
xy-1610xy CK7(Cytokeratin 7)human细胞角蛋白7抗原
xy-1106xy CK8(Cytokeratin 8)细胞角蛋白8（多肽）
xy-1330xy CKIP-1(casein kinase 2 interaction protein 1)酪蛋白激酶2相互作用蛋白1抗原
xy-1585xy CLCA4(Calcium-activated chloride channel 4)钙激活氯离子通道4抗原
xy-0548xy C-Mer/MERTK (proto-oncogene tyrosine kinase)c-mer原癌基因酪氨酸激酶抗原
xy-0842xy c-Myc tag c-Myc tag标签多肽
xy-2113xy AU5 tagAU5 tag标签抗原
xy-2114xy AU1 tag peptideAU1 tag标签多肽
xy-2115xy Glu-Glu Tag peptideGlu-Glu Tag多肽蛋白
xy-2074xy CNGA2(Cyclic Nucleotide Gated Cation Alpha 2)环核苷酸阳离子通道蛋白α2抗原
xy-1000xy CNP/CNPase ( 2',3'-cyclic-nucleotide 3'-phosphodiesterase)C型钠尿肽抗原 - Stemolecule Y27632
- xy-1272xy CNTF(Ciliary Neurotrophic Factor)睫状神经营养因子抗原
xy-1040xy factor V(Vcoagulation factor)凝血因子5抗体
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文献和实验相关实验
Preparation of Carboxypeptidase Y and Its Properties
while high efficiency habit in the scientific research. 【Requirement】 1. Use bread yeast as the original material to extract and condense carboxypeptidase Y, assay its biochemical properties. 2. Through gathering relevant published papers
用喹吖因（quinacrine）或喹吖因芥子（ quin- acrine mustard）染色，然后用荧光显微镜观察，在人的 Y染色体的长臂末端处能看到很强的荧光。在分裂期间的细胞核中也很容易看出这种荧光，因此把它叫做 Y染色质或 Y小体。由于 Y小体只有在男性中才能观察到，所以可用于人的性别鉴定。最近也已被奥林匹克运动会用于检查运动员的性别。然而这种现象只在人和大猩猩中观察到，在黑猩猩和猩猩等其他动物中， Y小体并不发出特别强的荧光。
每年到修改论文的时候，发现很多同学不懂图形和数据处理，出来的图形惨不忍睹。有的人想学没处学，有的根本不想学，最后的结果是研究生给本科生干活，老师给学生干活。所以有空的时候，想以这种方式写一点数据处理技术，给自己的未来减负。先从最简单的单X多Y图说起。 实验过程中经常遇到系列样品的表征数据，比如红外光谱、X-射线衍射等等，通常这些仪器测定的步长一致，也即X轴完全相同，这时候可以把系列数据绘制在一个图形中，图形的信息量丰富，也方便数据比较。例如这次本科论文中有一位同学的一组红外数据
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Stemolecule Y27632
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