Chemical Name: N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Appearance: White to off-white solid
Solubility: Soluble in DMSO (100 mM)
Storage:Store solid at -20 ºC for the stability of three years
储存液配制
储存液 (1 ml DMSO体系)
1 mM
5 mM
10 mM
25 mM
50 mM
质量(mg)
0.4138
2.0692
4.1383
10.3458
20.6915
PLX-4720(B-Raf(V600E) Inhibitor)结构式
参考文献
[1] Oltersdorf T, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 435(7042):677-81 (2005).
[2] Vogler M, et al. Bcl-2 inhibitors: small molecules with a big impact on cancer therapy. Cell Death Differ. 16(3):360-7 (2009).
[3] Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.Cancer Cell. 10(5):375-88 (2006).
[4] Zhai D, et al. Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ. 13(8):1419-21 (2006).