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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
蛋白表达区间:Met1-Ser486
- 保质期：
See instructions
- 英文名：
标签:C-6His
- 库存：
表达系统:Human Cells
- 供应商：
上海经科化学科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥1200.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥3520.0 |
| 规格： | 500ug | 产品价格： | ￥12320.0 |
| 规格： | 1mg | 产品价格： | ￥19200.0 |
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- The product is shipped at ambient temperature.
- Upon receipt, store it immediately at the temperature listed below.
- Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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文献和实验The MeCP2 helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein is present in cells throughout the body, although it is particularly abundant in brain cells.In the brain, the MeCP2 protein likely plays a role in maintaining connections (synapses) between neurons, where cell-to-cell communication occurs. The alternative splicing of proteins is critical for normal communication between neurons and may also be necessary for the function of other types of brain cells.
Purification of MeCP2-Containing Deacetylase from Xenopus laevis
by the histone deacetylase inhibitor Trichostatin A. In addition, two proteins have been identified, MeCP1 (6 ) and MeCP2 (7 ), that specifically bind to methylated DNA and mediate transcriptional repression. MeCP1 is a relatively uncharacterized complex
MECP2的突变可以导致持续性神经系统退化（neurodegenerative disorder）Rett综合症。这个x-染色体相关综合症（X-linked syndrome）主要在女性身上体现，但相对温和的突变也可以导致男性的智力障碍(mental retardation)。 （Figure 1： Pedigrees of the four families (L36, S49, T33, and T
Purification of the MeCP2/Histone Deacetylase Complex from Xenopus laevis
by the histone deacetylase inhibitor Trichostatin A. In addition, several proteins have been identified that specifically bind to methylated DNA (6-8) . Two of these methyl-DNA binding proteins, MeCP1 and MeCP2 , have been shown to mediate transcriptional
技术资料
