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- 2025年12月22日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
蛋白表达区间:Met1-Thr261
- 保质期：
See instructions
- 英文名：
标签:Tag free
- 库存：
表达系统:E.coli
- 供应商：
上海经科化学科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥840.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2520.0 |
| 规格： | 500ug | 产品价格： | ￥12320.0 |
| 规格： | 1mg | 产品价格： | ￥17600.0 |
- The product is shipped on dry ice/polar packs.
- Upon receipt, store it immediately at the temperature listed below.
- Store at ≤-70°C, stable for 6 months after receipt.
- Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
- Please minimize freeze-thaw cycles.
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文献和实验Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.
Quantitation of Heme Oxygenase (HO-1) Copies in Human Tissues by Competitive RT/PCR
A variety of oxidative stress-inducing agents, such as metals, ultra-violet (UV) light, heme, and hemoglobin have been implicated in the pathogenesis of the inflammatory process. The cellular response to such agents involves the production
zsping7411 有哪位高手知道PI3K细胞信号传导通路与HO-1的关系的，因为我发现在脑、肝、心肌器官的文献说PI3K通路激活，磷酸化PI3K增加，上调HO-1的表达，最后抑制细胞凋亡发挥保护作用，而在中性粒细胞（PMN）方面，PI3K激活促进PMN募集趋化作用，所以在胰腺炎、脓毒症等引起的ALI中应用PI3K抑制剂渥漫青霉素或LY294002则表现为抑制PMN在肺内聚集，所以减轻了ALI，似乎很矛盾，请问有谁能解释一下！非常感谢！可以回复至zsping
人 Neuritin 酶联免疫分析(ELISA) 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本 中Neuritin 的含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中人 Neuritin 水平。用纯化的 Neuritin 抗体 包被微孔板，制成固相抗体，往包被单抗的微孔中加入 Neuritin ，再与 HRP 标记的 Neuritin 抗体结合，形成抗体
技术资料