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文献和实验Cortical Neurons Culture to Study c-Jun N-Terminal Kinase Signaling Pathway
Excitotoxicity via N -methyl-d -aspartate receptors (NMDA-r) is a key mechanism of neurodegeneration following ischemia and other brain pathologies. We here describe the use of a fast, reliable and easily
Functional Identification of Peptide Receptors
. More recently, the dramatic development of genetic engineering has contributed to revealing the structure of complete genes coding for known, as well as novel, biologically active peptides, in addition to a large number of other peptide sequences of unknown
力后,BNP就开始由心肌细胞合成,但是并不是直接合成BNP,而是先合成pro-BNP(可以翻译成前脑钠肽或者脑钠肽原),pro-BNP具有108个氨基酸,在血液中会分解,产生BNP,分解下来的片段是其N端的76个氨基酸,这76个氨基酸就是NT-proBNP ,也就是经常检测的那个指标,剩下的32个氨基酸才叫BNP。没有NT-BNP的概念,所谓的NT-BNP应该是指NT-proBNP。有点类似于C肽与胰岛素的关系。从这个角度上来讲,都叫脑钠肽不妥,脑钠肽英文应该叫rain(脑) natriuretic(利钠
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