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R&D Systems货号338-AC-010重组人/小鼠/

大鼠激活素A上海睿安生物13611631389
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  • 338-AC-010
  • 2026年03月07日
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    • 保存条件：

      −20°C

    • 保质期：

      2年

    • 英文名：

      Recombinant Human/Mouse/Rat Activin A

    • 库存：

      100⁺支

    • 供应商：

      上海睿安生物13611631389

    • 规格：

      10ug/支

    R&D Systems货号338-AC-010重组人/小鼠/大鼠激活素A上海睿安生物13611631389

    Recombinant Human/Mouse/Rat Activin A Protein

    Catalog #:338-AC

    Background:Activin A

    Activin and Inhibin are members of the TGF-beta superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis (1‑7). Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfide-linked dimers of the bioactive proteins (8, 9). Activins are nonglycosylated homodimers or heterodimers of various beta subunits ( beta A, beta B, beta C, and beta E in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two beta A chains. The beta A subunit can also heterodimerize with a beta B or beta C subunit to form Activin AB and Activin AC, respectively (10). The 14 kDa mature human beta A chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat beta A. 

     
    Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK-4 (7, 11). Signaling through this receptor complex leads to Smad activation and regulation of activin-responsive gene transcription (7, 11). The bioactivity of Activin A is regulated by a variety of mechanisms (11). BAMBI, Betaglycan, and Cripto are cell‑associated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly (12‑14). The intracellular formation of Activin A can be prevented by the incorporation of the beta A subunit into Activin AC or Inhibin A (3, 10). And the bioavailability of Activin A is restricted by its incorporation into inactive complexes with alpha 2-Macroglobulin, Follistatin, and FLRG (15, 16). 
     
    Activin A is involved in the differentiation of various cell and tissue types. The induction of definitive endoderm by Activin A is required in differentiation protocols of induced pluripotent stem cells (iPSCs) (17, 18). In vitro models of human gametogenesis use prolonged Activin A supplementation to human embryonic stem cells for differentiation into human primordial germ cell-like cells (19). Activin A can also be used to maintain cells in vitro, as is the case for iPSC-derived nephron cells that can then be used in disease modeling, drug screening and in regenerative medicine (20). 
     
    Activin A is an important factor for tumor cells to evade the immune system as Activin A can act on surrounding immune cells to decrease their antitumor activity (21). Activin A also promotes migration and growth of tumors, making it a target for cancer therapies (22). Specifically, research has shown that interfering with Activin A activity can assist in overcoming CD8 T-cell exclusion and immunotherapy resistance (23). In bone marrow-derived stem cell transplants for treatment of diabetes, Activin A enhances migration and homing of stem cells towards pancreatic lineage(24).

    产品细节图片1

    产品细节图片2

    References:

    1. Kumanov, P. et al. (2005) Reprod. Biomed. Online 10:786.
    2. Maeshima, A. et al. (2008) Endocr. J. 55:1.
    3. Rodgarkia-Dara, C. et al. (2006) Mutat. Res. 613:123.
    4. Werner, S. and C. Alzheimer (2006) Cytokine Growth Factor Rev. 17:157.
    5. Xu, P. and A.K. Hall (2006) Dev. Biol. 299:303.
    6. Shav-Tal, Y. and D. Zipori (2002) Stem Cells 20:493.
    7. Chen, Y.G. et al. (2006) Exp. Biol. Med. 231:534.
    8. Gray, A.M. and A.J. Mason (1990) Science 247:1328.
    9. Mason, A.J. et al. (1996) Mol. Endocrinol. 10:1055.
    10. Thompson, T.B. et al. (2004) Mol. Cell. Endocrinol. 225:9.
    11. Harrison, C.A. et al. (2005) Trends Endocrinol. Metab. 16:73.
    12. Onichtchouk, D. et al. (1999) Nature 401:480.
    13. Gray, P.C. et al. (2002) Mol. Cell. Endocrinol. 188:254.
    14. Kelber, J.A. et al. (2008) J. Biol. Chem. 283:4490.
    15. Phillips, D.J. et al. (1997) J. Endocrinol. 155:65.
    16. Schneyer, A. et al. (2003) Endocrinology 144:1671.
    17. Ghorbani-Dalini, S. et al. (2020) 3 Biotech. 10:215.
    18. Mennen, R. H. et al. (2022) Reprod Toxicol. 107:44.
    19. Mishra, S. et al. (2021) Stem Cells. 39:551.
    20. Tanigawa, S. et al. (2019) Stem Cell Reports 13:322.
    21. Cangkrama, M. et al. (2020) Trends Mol. Med. 26:1107.
    22. Ries, A. et al. (2020) Expert Opin. Ther. Targets. 24:985.
    23. Pinjusic, K. et al. (2022) J. Immunother. Cancer. 10:e004533.
    24. Dadheech, N. et al. (2020) Stem Cell Res. Ther. 11:327.

    产品细节图片3

    产品细节图片4

    产品种类丰富，质量稳定可靠.
    R&D总公司于1976年成立于美国，在美国NASDAQ上市(TECH)。公司一直致力于各种细胞因子及其相关分子的生产研发。R&D的产品覆盖面广，种类丰富，质量稳定可靠，其生产的各种ELISA试剂盒、重组因子及抗体以其卓越的品质赢得了世界各国科研及临床诊断机构的青睐。
    订购信息:

    货号产品描述规格
    DEP00Human Erythropoietin Quantikine IVD ELISA Kit 人促红细胞生成素IVD ELISA试剂盒1KT
    DVE00Human VEGF Quantikine ELISA Kit 人血管内皮生长因子ELISA试剂盒1KT
    1324-WN-002Recombinant Mouse Wnt-3a 重组鼠Wnt-3a2UG
    233-FB-025Recombinant Human FGF basic (146 aa) 重组人FGF basic (146 aa)25UG
    240-B-002Recombinant Human TGF-beta 1 重组人FGF basic (146 aa)2UG
    293-VE-010Recombinant Human VEGF 165 重组人VEGF 16510UG
    314-BP-010Recombinant Human BMP-4 重组人BMP-410UG
    338-AC-010Recombinant Human/Mouse/Rat Activin A 重组人/小鼠/大鼠激活素A10UG
    338-AC-050Recombinant Human/Mouse/Rat Activin A 重组人/小鼠/大鼠激活素A50UG
    355-BM-010Recombinant Human BMP-2 重组人BMP-210UG

    产品细节图片5
    睿安公司专业技术服务
    荧光定量PCR、甲基化检测、文库构建、原核和真核蛋白表达、高通量测序、抗体定制服务、WB检测、IHC检测。

    睿安公司代理及优势品牌：
    免疫学：Abgent、CST、R&D、Abcam、BD、Epitomics、Santa cruz、Jackson
    耗材类： Ammex、Fisher、Bioplastics、Axygen、Corning、Greiner，Nunc-Nalgene
    分子和细胞：Fermentas、hyclone-pierce、Qiagen、Bio-Rad
    综合类： Sigma、 MERCK、Millipore、Roche、Invitrogen
    自主品牌：Rainbio 生化类：Sigma-Vetec 、 MP
    肥胖代谢类：Biovendor、ALPCO
    表观遗传：Zymo ACTIVE MOTIF 神经和信号传导：Tocris
    其他类： Biovision、Biocolor、Covance、Cytoskeleton、ebioscience、GE、Genetex、Invivogen、Omega、
    Proteintech 、Socorex 、Vector

    一、╳※试剂※╳:
    常规血清优势供应:VivaCell血清、Gemini货号900-108血清、Gemini血清、Gibco血清(10099-141澳洲血清、10270-106南美血清、16000-044血清)、BI血清BI货号04-001-1ACS、Sigma货号F8318-500ml澳洲胎牛血清、Sigma货号F8687澳洲胎牛血清、Sigma货号F2442-500ml特级胎牛血清、ScienCell货号0500澳洲胎牛血清、Cegrogen货号A0500-3010胎牛血清、Cegrogen货号B0500-5010新生牛血清、康源血清
    培养基(包括无血清)、冻存液(包括无血清)，包括:友康Yocon
    Merck(Millipore/Sigma/Roche/KaPa/Supelco/Avanti/Corning/Brand)正式授权代理、博奥龙Biodragon独家总代理、EFL独家总代理、碧云天Beyotime代理
    ☆☆☆☆☆☆Beckman货号A63881纯化磁珠Agencourt AMPure XP(60ml/瓶)/A63882(450ml/瓶)；Beckman货号B23317核酸片段筛选试剂盒Agencourt SPRIselect(5ml/瓶)
    分子类:Biotium货号41003的GelRed染料、货号31000的EvaGreen染料、Zymo Research、Qiagen
    饲料类:Research Diets、Dyets
    二、╳※耗材※╳:
    洁特JET耗材(各类常规用实验耗材)、赛普Cellpro耗材/KirGen耗材、博麦迪(常规的)各类试剂瓶
    Bioplastics
    Thermo Fisher Scientific的很多产品线，包括旗下的:
    一、Nunc耗材
    二、QSP耗材(各类吸头/滤芯吸头、离心管、PCR管等)
    三、Nalgene耗材仪器
    四、FisherBrand耗材仪器(含各类盖玻片载玻片等)
    五、Lab_Serv耗材仪器
    六、Finnpipette移液器(如：F1系列、F2系列、F3系列等等各类型号的移液器)
    七、Abgene耗材
    畅销款:我们是常备有大量现货的
    产品细节图片6
    ※╳√√✓✔√✓✔√✓✔上海睿安生物科技有限公司成立于2009年，专注于为生命科学和生物技术领域的客户提供优质的产品与服务。代理了多家欧美知名品牌，如美国Thermo Fisher耗材(包括旗下Nunc、QSP、Nalgene、FisherBrand、Lab_Serv耗材仪器、Finnpipette移液器、Abgene耗材，等等)、默克Merck-Millipore/Sigma/Roche/KaPa/Supelco/Avanti/Corning/Brand)、Zymo Research、洁特JET耗材(各类常规用实验耗材)、赛普Cellpro耗材、博奥龙Biodragon独家总代理、EFL独家总代理、碧云天Beyotime代理、Eppendorf、友康Yocon、Research Diets高脂饲料，IBL、BioVendor、Mercodia、ShiBayaji代谢类产品、Axygen-Corning长期大量耗材备货、BioCaot畅销款长期备货，VivaCell血清、Gemini血清、Gibco血清，BI血清现货、ScienCell血清、Sigma血清、Moregate血清、Cegrogen血清、Pierce发光试剂、Fermentas、Invitrogen、Abcam、CST、BD、SAB、R&D systems、Beckman、Qiagen、BD Pharmingen、Biolegend、Jackson、Miltenyi、MP Biomedicals、Biotium更好的荧光试剂产品等品牌。睿安生物始终将“提供更好的产品和服务”作为企业发展的目标和努力的方向，并将通过优质的售前与售后服务，始终如一地为客户提供高质量的产品和服务，我们也希望能得到相关领域中更多老师和同仁们的指导和鞭策，为共创优秀品牌而努力奋斗！询订╳直线13611631389微信号

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    图标文献和实验
    该产品被引用文献

    R&D Systems货号338-AC-010重组人/小鼠/大鼠激活素A上海睿安生物13611631389

    Recombinant Human/Mouse/Rat Activin A Protein

    Catalog #:338-AC

    Background:Activin A

    Activin and Inhibin are members of the TGF-beta superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis (1‑7). Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfide-linked dimers of the bioactive proteins (8, 9). Activins are nonglycosylated homodimers or heterodimers of various beta subunits ( beta A, beta B, beta C, and beta E in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two beta A chains. The beta A subunit can also heterodimerize with a beta B or beta C subunit to form Activin AB and Activin AC, respectively (10). The 14 kDa mature human beta A chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat beta A. 

     
    Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK-4 (7, 11). Signaling through this receptor complex leads to Smad activation and regulation of activin-responsive gene transcription (7, 11). The bioactivity of Activin A is regulated by a variety of mechanisms (11). BAMBI, Betaglycan, and Cripto are cell‑associated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly (12‑14). The intracellular formation of Activin A can be prevented by the incorporation of the beta A subunit into Activin AC or Inhibin A (3, 10). And the bioavailability of Activin A is restricted by its incorporation into inactive complexes with alpha 2-Macroglobulin, Follistatin, and FLRG (15, 16). 
     
    Activin A is involved in the differentiation of various cell and tissue types. The induction of definitive endoderm by Activin A is required in differentiation protocols of induced pluripotent stem cells (iPSCs) (17, 18). In vitro models of human gametogenesis use prolonged Activin A supplementation to human embryonic stem cells for differentiation into human primordial germ cell-like cells (19). Activin A can also be used to maintain cells in vitro, as is the case for iPSC-derived nephron cells that can then be used in disease modeling, drug screening and in regenerative medicine (20). 
     
    Activin A is an important factor for tumor cells to evade the immune system as Activin A can act on surrounding immune cells to decrease their antitumor activity (21). Activin A also promotes migration and growth of tumors, making it a target for cancer therapies (22). Specifically, research has shown that interfering with Activin A activity can assist in overcoming CD8 T-cell exclusion and immunotherapy resistance (23). In bone marrow-derived stem cell transplants for treatment of diabetes, Activin A enhances migration and homing of stem cells towards pancreatic lineage(24).

    引用文献图片1

    引用文献图片2

    References:

    1. Kumanov, P. et al. (2005) Reprod. Biomed. Online 10:786.
    2. Maeshima, A. et al. (2008) Endocr. J. 55:1.
    3. Rodgarkia-Dara, C. et al. (2006) Mutat. Res. 613:123.
    4. Werner, S. and C. Alzheimer (2006) Cytokine Growth Factor Rev. 17:157.
    5. Xu, P. and A.K. Hall (2006) Dev. Biol. 299:303.
    6. Shav-Tal, Y. and D. Zipori (2002) Stem Cells 20:493.
    7. Chen, Y.G. et al. (2006) Exp. Biol. Med. 231:534.
    8. Gray, A.M. and A.J. Mason (1990) Science 247:1328.
    9. Mason, A.J. et al. (1996) Mol. Endocrinol. 10:1055.
    10. Thompson, T.B. et al. (2004) Mol. Cell. Endocrinol. 225:9.
    11. Harrison, C.A. et al. (2005) Trends Endocrinol. Metab. 16:73.
    12. Onichtchouk, D. et al. (1999) Nature 401:480.
    13. Gray, P.C. et al. (2002) Mol. Cell. Endocrinol. 188:254.
    14. Kelber, J.A. et al. (2008) J. Biol. Chem. 283:4490.
    15. Phillips, D.J. et al. (1997) J. Endocrinol. 155:65.
    16. Schneyer, A. et al. (2003) Endocrinology 144:1671.
    17. Ghorbani-Dalini, S. et al. (2020) 3 Biotech. 10:215.
    18. Mennen, R. H. et al. (2022) Reprod Toxicol. 107:44.
    19. Mishra, S. et al. (2021) Stem Cells. 39:551.
    20. Tanigawa, S. et al. (2019) Stem Cell Reports 13:322.
    21. Cangkrama, M. et al. (2020) Trends Mol. Med. 26:1107.
    22. Ries, A. et al. (2020) Expert Opin. Ther. Targets. 24:985.
    23. Pinjusic, K. et al. (2022) J. Immunother. Cancer. 10:e004533.
    24. Dadheech, N. et al. (2020) Stem Cell Res. Ther. 11:327.

    引用文献图片3

    引用文献图片4

    产品种类丰富，质量稳定可靠.
    R&D总公司于1976年成立于美国，在美国NASDAQ上市(TECH)。公司一直致力于各种细胞因子及其相关分子的生产研发。R&D的产品覆盖面广，种类丰富，质量稳定可靠，其生产的各种ELISA试剂盒、重组因子及抗体以其卓越的品质赢得了世界各国科研及临床诊断机构的青睐。
    订购信息:

    货号产品描述规格
    DEP00Human Erythropoietin Quantikine IVD ELISA Kit 人促红细胞生成素IVD ELISA试剂盒1KT
    DVE00Human VEGF Quantikine ELISA Kit 人血管内皮生长因子ELISA试剂盒1KT
    1324-WN-002Recombinant Mouse Wnt-3a 重组鼠Wnt-3a2UG
    233-FB-025Recombinant Human FGF basic (146 aa) 重组人FGF basic (146 aa)25UG
    240-B-002Recombinant Human TGF-beta 1 重组人FGF basic (146 aa)2UG
    293-VE-010Recombinant Human VEGF 165 重组人VEGF 16510UG
    314-BP-010Recombinant Human BMP-4 重组人BMP-410UG
    338-AC-010Recombinant Human/Mouse/Rat Activin A 重组人/小鼠/大鼠激活素A10UG
    338-AC-050Recombinant Human/Mouse/Rat Activin A 重组人/小鼠/大鼠激活素A50UG
    355-BM-010Recombinant Human BMP-2 重组人BMP-210UG

    引用文献图片5
    睿安公司专业技术服务
    荧光定量PCR、甲基化检测、文库构建、原核和真核蛋白表达、高通量测序、抗体定制服务、WB检测、IHC检测。

    睿安公司代理及优势品牌：
    免疫学：Abgent、CST、R&D、Abcam、BD、Epitomics、Santa cruz、Jackson
    耗材类： Ammex、Fisher、Bioplastics、Axygen、Corning、Greiner，Nunc-Nalgene
    分子和细胞：Fermentas、hyclone-pierce、Qiagen、Bio-Rad
    综合类： Sigma、 MERCK、Millipore、Roche、Invitrogen
    自主品牌：Rainbio 生化类：Sigma-Vetec 、 MP
    肥胖代谢类：Biovendor、ALPCO
    表观遗传：Zymo ACTIVE MOTIF 神经和信号传导：Tocris
    其他类： Biovision、Biocolor、Covance、Cytoskeleton、ebioscience、GE、Genetex、Invivogen、Omega、
    Proteintech 、Socorex 、Vector

    一、╳※试剂※╳:
    常规血清优势供应:VivaCell血清、Gemini货号900-108血清、Gemini血清、Gibco血清(10099-141澳洲血清、10270-106南美血清、16000-044血清)、BI血清BI货号04-001-1ACS、Sigma货号F8318-500ml澳洲胎牛血清、Sigma货号F8687澳洲胎牛血清、Sigma货号F2442-500ml特级胎牛血清、ScienCell货号0500澳洲胎牛血清、Cegrogen货号A0500-3010胎牛血清、Cegrogen货号B0500-5010新生牛血清、康源血清
    培养基(包括无血清)、冻存液(包括无血清)，包括:友康Yocon
    Merck(Millipore/Sigma/Roche/KaPa/Supelco/Avanti/Corning/Brand)正式授权代理、博奥龙Biodragon独家总代理、EFL独家总代理、碧云天Beyotime代理
    ☆☆☆☆☆☆Beckman货号A63881纯化磁珠Agencourt AMPure XP(60ml/瓶)/A63882(450ml/瓶)；Beckman货号B23317核酸片段筛选试剂盒Agencourt SPRIselect(5ml/瓶)
    分子类:Biotium货号41003的GelRed染料、货号31000的EvaGreen染料、Zymo Research、Qiagen
    饲料类:Research Diets、Dyets
    二、╳※耗材※╳:
    洁特JET耗材(各类常规用实验耗材)、赛普Cellpro耗材/KirGen耗材、博麦迪(常规的)各类试剂瓶
    Bioplastics
    Thermo Fisher Scientific的很多产品线，包括旗下的:
    一、Nunc耗材
    二、QSP耗材(各类吸头/滤芯吸头、离心管、PCR管等)
    三、Nalgene耗材仪器
    四、FisherBrand耗材仪器(含各类盖玻片载玻片等)
    五、Lab_Serv耗材仪器
    六、Finnpipette移液器(如：F1系列、F2系列、F3系列等等各类型号的移液器)
    七、Abgene耗材
    畅销款:我们是常备有大量现货的
    引用文献图片6
    ※╳√√✓✔√✓✔√✓✔上海睿安生物科技有限公司成立于2009年，专注于为生命科学和生物技术领域的客户提供优质的产品与服务。代理了多家欧美知名品牌，如美国Thermo Fisher耗材(包括旗下Nunc、QSP、Nalgene、FisherBrand、Lab_Serv耗材仪器、Finnpipette移液器、Abgene耗材，等等)、默克Merck-Millipore/Sigma/Roche/KaPa/Supelco/Avanti/Corning/Brand)、Zymo Research、洁特JET耗材(各类常规用实验耗材)、赛普Cellpro耗材、博奥龙Biodragon独家总代理、EFL独家总代理、碧云天Beyotime代理、Eppendorf、友康Yocon、Research Diets高脂饲料，IBL、BioVendor、Mercodia、ShiBayaji代谢类产品、Axygen-Corning长期大量耗材备货、BioCaot畅销款长期备货，VivaCell血清、Gemini血清、Gibco血清，BI血清现货、ScienCell血清、Sigma血清、Moregate血清、Cegrogen血清、Pierce发光试剂、Fermentas、Invitrogen、Abcam、CST、BD、SAB、R&D systems、Beckman、Qiagen、BD Pharmingen、Biolegend、Jackson、Miltenyi、MP Biomedicals、Biotium更好的荧光试剂产品等品牌。睿安生物始终将“提供更好的产品和服务”作为企业发展的目标和努力的方向，并将通过优质的售前与售后服务，始终如一地为客户提供高质量的产品和服务，我们也希望能得到相关领域中更多老师和同仁们的指导和鞭策，为共创优秀品牌而努力奋斗！询订╳直线13611631389微信号
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