重组人、小鼠、大鼠TGF beta 3蛋白

重组人、小鼠、大鼠TGF beta 3蛋白相关信息：
英文名称
Recombinant human/mouse/rat TGF-Beta 3 protein (HEK293)
中文名称
重组人、小鼠、大鼠TGF beta 3蛋白
英文别名
Transforming growth factor beta-3 proprotein; TGFB3; ARVD; FLJ16571; MGC105479; MGC118722; TGF beta 3; TGF beta3; TGF-beta-3; TGF-beta 3; TGFB 3; Transforming growth factor beta-3; TGFB3_HUMAN; Recombinant human/mouse/rat TGF-Beta 3 protein (HEK293)
蛋白细胞定位
分泌型蛋白
分子量
12/47
浓度
＞0.5 mg/ml
储存液
Lyophilized from 0.22 um filtered solution in PBS (pH=7.4) with 5 mM DTT. Normally 5% trehalose is added as protectant before Lyophilization.
保存条件
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

重组人、小鼠、大鼠TGF beta 3蛋白

背景资料：Transforming growth factor beta s (TGF beta s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF beta. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. TGF beta 3 mediates many intercellular interactions that occur during embryonic development, cell differentiation and epithelial homeostasis. TGF beta 3 overexpresses in extramammary Paget’s disease (EPD) and downregulates in Bowen’s disease, indicating that its expression is a useful indicator of tumor activity. TGF beta 3 levels strongly correlate with IGF-1 and osteocalcin levels in serum. Significant amounts of TGF beta 3 circulation appear to be representative of TGF beta 3 expression in bone and may in part be derived from bone. Glucocorticoids may block TGF beta production by modulating mRNA levels and c-Jun activity.

重组人、小鼠、大鼠TGF beta 3蛋白应用：仅供研究使用，不用于临床诊断！




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