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- 保存条件：
-20℃
- 克隆性：
单克隆
- 抗体名：
Androgen Receptor (AR) (AA 365-392) 抗体
- 规格：
0.1ml/0.2ml
Androgen Receptor (AR)
别名 AR, NR3C4, AIS, DHTR, HUMARA, HYSP1, KD, SBMA, SMAX1, TFM, AW320017, Tfm, Andr
抗原表位
其他选择 AA 365-392
适用
其他选择 人, 小鼠
宿主
其他选择 兔
克隆类型 (克隆位点)
多克隆 (RB2579)
标记
其他选择 非结合性
应用范围
其他选择 Western Blotting (WB), 免疫组织化学（IHC）
Pubmed 3个引用可参考
规格 400 μL
发货至 中国 (更改)
发货时间 9至13个工作日
产品编号 yb389077
产品细节 Androgen Receptor (AR) (AA 365-392) 抗体
免疫原 This Androgen Receptor (ANDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 AA from human Androgen Receptor (ANDR).
克隆位点 RB2579
亚型 Ig
特异性 This ANDR antibody is generated from rabbits immunized with the KLH conjugated synthetic peptide HPHARIKLENPLD containing a predicted sumoylation site from the central region of human ANDR.
预测反应 Pig (Porcine),Monkey
纯化方法 This antibody is purified through a protein A column, followed by peptide affinity purification.
目标详细情况 Androgen Receptor (AR) (AA 365-392) 抗体
别名 Androgen Receptor (ANDR)
背景 Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor, sumoylation of ANDR represses androgen receptor dependent transcription.
Synonyms: Androgen receptor, AR
分子量 98988 DA
基因ID 367
UniProt Q5JUN9
研究领域 Apoptosis/Necrosis, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
使用细节Androgen Receptor (AR) (AA 365-392) 抗体
应用备注 WB = 1:1000, IHC = 1:10-50
限制 仅限研究用
贮存及处理 Androgen Receptor (AR) (AA 365-392) 抗体
状态 Liquid
浓度 0.5 mg/mL
缓冲液 PBS with 0.09 % (W/V) sodium azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C/-20 °C
储存方法 Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
有效期 6 months
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文献和实验Analysis of Androgen Receptor SUMOylation
Androgen receptor (AR) is a ligand-controlled transcription factor that is deregulated and therefore targeted in prostate cancer. In addition to androgens, AR is regulated by post-translational modifications (PTMs). SUMOylation, conjugation
Analysis of Interdomain Interactions of the Androgen Receptor
High-affinity binding of testosterone or dihydrotestosterone to the androgen receptor (AR) triggers the androgen-dependent AR NH2 - and carboxyl-terminal (N/C) interaction between the AR NH2 -terminal FXX LF motif and the activation function
In Vitro and In Vivo Silencing of the Androgen Receptor
The androgen receptor (AR) plays a pivotal role in the progression of prostate cancer from the androgen-dependent to the castration-resistant state, making it a potential target for therapy. In this chapter, we describe the preparation
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