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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 克隆性:
单克隆
- 抗体名:
Integrin alpha 2 (ITGA2) 抗体
- 规格:
0.1ml/0.2ml
Integrin alpha 2 (ITGA2)
别名 PGI, gpi, pgi-1, wu:fc02c05, zgc:86919, CD49B, DX5, BR, GPIa, HPA-5, VLA-2, VLAA2
适用
其他选择 人, 猴
宿主
其他选择 小鼠
克隆类型 (克隆位点)
单克隆 (AK7)
标记
其他选择 非结合性
应用范围
其他选择 流式细胞分析技术(FACS)
Pubmed 4个引用可参考
规格 0.2 mg
发货至 中国 (更改)
发货时间 29至35个工作日
产品编号 yb118699
产品细节Integrin alpha 2 (ITGA2) 抗体
免疫原 Spleen cells from immunised mice were fused with cells of the mouse NS1 myeloma cell line.
克隆位点 AK7
亚型 IgG1
特异性 This antibody recognises the integrin alpha2 subunit, which is a 160 kDa glycoprotein that non-covalently associates with the 130 kDa integrin beta1 subunit to form the VLA-2 complex. CD49b is expressed by platelets, long term cultivated T cells, endothelial cells, monocytes and most adherent cell lines. Cross reacts with Cynomolgus monkey (3), Baboon and Rhesus monkey.
纯化方法 Affinity chromatography on Protein G
目标详细情况Integrin alpha 2 (ITGA2) 抗体
别名 CD49b / ITGA2
背景 CD49b is a 160kD glycoprotein that non-covalently associates with the 130kD integrin beta 1 subunit to form the VLA-2 complex. CD49b is expressed by platelets, long term cultivated T cells, approximately 50 % of monocytes and most adherent cell lines. MCA743 inhibits cell attachment to collagen.Synonyms: CD49 antigen-like family member B, Collagen Receptor, GPIa, ITGA-2, Integrin alpha-2, Platelet membrane glycoprotein Ia, VLA-2 alpha, VLA2
基因ID 3673
NCBI登录号 NP_002194
UniProt P17301
研究领域 CD Antigens, Surface Receptors of Immune Cells, Cell/Tissue Markers, Extracellular Matrix, Signaling
使用细节 Integrin alpha 2 (ITGA2) 抗体
应用备注 Flow cytometry: 1/50 - 1/100, use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunohistochemistry on frozen sections: 1/500 - 1/1000. Recommended positive control tissue: Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
贮存及处理 Integrin alpha 2 (ITGA2) 抗体
浓度 1.0 mg/mL
缓冲液 PBS containing 0.09 % Sodium Azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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文献和实验;2与配体的作用可以协同TCR/CD3介导的淋巴细胞增殖和细胞因子产生,提示淋巴细胞与胞外基质的作用可能影响其活化状态。此外单核细胞及中性粒细胞表面integrin分子与配体的作用也参与诱导细胞产生炎症因子的过程。 (一)粘附分子与细胞内酪氨酸磷酸化 酪氨酸磷酸化是细胞内信号传导的一个重要途径,而integrin分子与某些细胞内的酪氨酸磷酸化发生有关。血小板活化过程伴随着广泛的细胞内蛋白酪氨酸磷酸化,integrin分子&alpha
associated alpha and beta subunits CD11a Aka alpha L; LFA-1 (in complex with CD18) An alpha integrin chain that binds to CD18 and mediates leukocyte adhesion and lymphocyte recirculation through lymph
CD51 分子 CD51 常用单克隆抗体或代号: 13C2,23C6,NK1- M7;(VNRa 链,integrin a V) 主要表达细胞: Pt,En,Meg [Pt] 分子质量(kDa)和结构: gp150,与CD61组成二聚体 功 能: 粘附VN、FN和vWF CD51 Aka vitronectin receptor-alpha chain; beta chain
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