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- yb673854
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20℃
- 克隆性：
单克隆
- 抗体名：
Fibrinogen 抗体
- 规格：
0.1ml/0.2ml
Fibrinogen
别名 fib2, MGC53620, fibrinogen, sb:cb892, wu:fa55c12, wu:fb20e08, wu:fb59b03, wu:fi39d04, zgc:92117
适用
其他选择 人
宿主
其他选择 兔
克隆类型
多克隆
标记
其他选择 非结合性
Fibrinogen 抗体应用范围
其他选择 Western Blotting (WB), 免疫组织化学石蜡技术（IHC-P）, 免疫萤光石蜡技术（IF-P）
规格 100 μL
发货至 中国 (更改)
产品编号 yb673854
产品细节
免疫原 Fibrinogen from human plasma
亚型 IgG
纯化方法 Purified by Protein A.
目标详细情况
别名 Human Fibrinogen
背景 Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Synonyms: Fib2, Fibrinogen alpha chain, FGA
Fibrinogen 抗体基因ID 2243
UniProt P02671
使用细节
应用备注 WB: (1:100-1000), IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.
限制 仅限研究用
贮存及处理
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
Fibrinogen 抗体注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store at -20 °C for 12 months.
有效期 12 months
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文献和实验Fibrinogen is the final essential building block of the clotting process. Thus, all of the preliminary “cause and effect” events in the clotting cascade rely on the work of this molecule to measure their success. The most commonly used
Ligand-Binding Assays: Fibrinogen
The fibrinogen receptor on platelets is glycoprotein (GP) IIb/IIIa, also known as αIIb β3 . This receptor can bind to immobilized fibrinogen in its resting state. Binding to soluble fibrinogen, however, requires activation of the receptor
抗体的结构决定了其对应的功能，同一抗体的V区和C区的氨基酸组成和顺序不同，决定了其功能上的差异。V区和C区的组成和结构，决定了抗体的生物学功能。 图1：抗体的主要功能（图片来源：Abbas et al: Cellular and Molecular Immunology, 7e.) 1、特异性识别功能 抗体可以通过其结构上的可变区域与抗原结合，同时，具有极高的特异性。这种特异性识别功能可以使抗体识别和结合到感染的病原体，肿瘤细胞等不同种类的分子，帮助免疫系统识别并定位到这些分子，进而启动
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