TGF beta R1 (AA 310-360) 抗体

TGF beta R1 (AA 310-360) 抗体抗原
TGF beta R1
抗原表位
其他选择 AA 310-360
适用
其他选择 人, 小鼠, 大鼠
宿主
其他选择 兔
克隆类型
多克隆
标记
其他选择 非结合性
TGF beta R1 (AA 310-360) 抗体应用范围
其他选择 Western Blotting (WB), 免疫组织化学石蜡技术（IHC-P）, 免疫萤光石蜡技术（IF-P）
规格 100 μL
发货至 中国 (更改)
产品编号 yb671256
产品细节
免疫原 KLH conjugated synthetic peptide derived from human TGF-beta R1
亚型 IgG
纯化方法 Purified by Protein A.
目标详细情况
TGF beta R1 (AA 310-360) 抗体背景 Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
Synonyms: AAT5, ALK5, ESS1, LDS1, MSSE, SKR4, ALK-5, LDS1A, LDS2A, TGFR-1, ACVRLK4, TGF-beta receptor type-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, Serine/threonine-protein kinase receptor R4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I, TGFBR1
Subcellular locations: Cytoplasm
基因ID 7046
UniProt P36897
使用细节
应用备注 WB: (1:100-1000), IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.
限制 仅限研究用
贮存及处理
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
TGF beta R1 (AA 310-360) 抗体注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store at -20 °C for 12 months.
有效期 12 months