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文献和实验Designing TCR for Cancer Immunotherapy
the circumvention of tolerance to tumor-associated (self) antigens (TAA). This chapter reports on the identification of the α and β chains of the heterodimeric TCR derived from a mouse T-cell clone. The related DNA fragments are inserted into a retroviral vector
Binding Kinetics of Superantigen with TCR and MHC Class II
that much of the contact is with main-chain atoms instead of side-chain residues of TCR Vβ (5 ,8 ,9 ). Taking into account these differences and particularly the strength of the SAg effect on T-cell activation, it was reasonable to predict that bacterial SAgs
cell receptor (TCR) repertoires (1 ,2 ). Thus, TCRαV and TCRβV repertoires have been studied for characterizing of T cells that may play major role in peripheral blood or pathological lesions of patients with autoimmune diseases (3 –6 ).
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