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- 克隆性：
单克隆
- 抗体英文名：
Anti-LEF-1(lymphoid
- 抗体名：
淋巴增强因子-1抗体
Lymphoid enhancer factor, LEF1, is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer.
LEF1 is expressed during development in many different differentiating tissues, and in a few tissues after birth. LEF1 expression is required for proper development of breast, teeth, hair, whiskers and the trigeminal nerve. It is redundant with TCF1 (for T cell Factor 1) for correct development of T lymphocytes in the thymus. LEF1 is a 399 amino acid protein. Alternative splice forms of LEF1 and other LEF/TCF family members have been identified, but the expression pattern and relative abundance of these alternative forms have not been well studied. They can appear on immunoblots as small immunoreactive forms.
mol wt:44kDa
Other Aliases:
lymphoid enhancing factor-1; Transcription factor T cell specific 1 alpha ; DKFZp586H0919; LEF 1; LEF1; Lymphoid enhancer binding factor 1; T cell specific transcription factor 1 alpha; TCF 1 alpha; TCF1 alpha; TCF1alpha
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文献和实验wywdxfsh 在ncbi上查不到这个咚咚，只有转录因子 transcription factor 4 我做的小鼠的 freecell T细胞因子(TCF)/淋巴增强因子(LEF)是Wnt信号传导通路的主要信号分子。TCF/LEF家族包括LEF-1、TCF-1、 TCF-3、TCF-4。其中TCF-4是Wnt信号传导通路的一个重要的分子，并且在肿瘤的发生过程中起重要作用. SEE: http
熬夜不睡，免疫崩溃！长期睡眠不足会增加炎症疾病风险，即使补觉也难以逆转
细胞分化。 在 10 周的睡眠恢复后，髓系增强因子的许多变化都保留了下来，但淋巴系增强因子却没有，这表明睡眠对造血干细胞谱系发育的影响是长期的。这些分析表明，SF 使造血系统向髓系倾斜，淋巴系分化能力下降。并且在后续的免疫挑战测试中，睡眠干扰组小鼠的炎症反应更加强烈，血液中单核细胞增多、血浆细胞因子水平增加、骨髓造血增强。 图片来源：Journal of Experimental Medicine 通过分析随时间变化的血液集群动态，发现睡眠干扰加速了一些细胞簇的扩增，而另一些细胞簇则消失了，这与加速中性漂移
尘螨酶性变应原的作用机制 至少有4种尘螨酶 活性变应原具备蛋白水解酶作用，此类酶可通过非细胞毒性作用造成上皮细胞间的关系破坏，使变应原轻易通过气道黏膜屏障。组织学显示，细胞之间侧面及基底侧面失去黏附，酶直接损伤细胞内的连接。尘螨酶性变应原的致敏途径有：①酶的直接作用，使气管黏膜通透性增加；②上皮细胞吞转作用(transcytosis)；③直接刺激支气管相关淋巴细胞；④蛋白酶性抗原的局部黏附，导致胞内黏附及交流的损伤、黏膜的损伤，使APC能够与抗原接触而诱发一系
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