- 询价
- Merck millipore
- 中国/美国/德国
- hz-10345-RP03
- 2025年07月15日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
Granzyme B ( GZMB )抗体
免疫原 :
Recombinant human Granzyme B protein ( Catalog#10345-H08H )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human Granzyme B ( rhGranzyme B; Catalog#10345-H08H; NP_004122.1; Met 1- Tyr 247 ). Total IgG was purified by Protein A affinity chromatography.
Granzyme B ( GZMB )抗体Background
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of Granzyme B have been identified including the key substrate caspase-3, ICAD and Bid. Granzyme B is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.
Granzyme B ( GZMB )抗体相关产品如下：
hz-1064hz Klf4 (Kruppel likefactor 4)肠道内富含的Kruppel样因子抗原
hz-2019hz phospho-KLF5/Krueppel-like factor 5 (pSer272)磷酸化肠道内富含的Kruppel样因子5抗原
hz-2020hz phospho-Klf5/CKLF/Kruppel like factor 5, Human, mo, rat, horse, bovine, rabbit, pig, dog磷酸化肠道内富含的Kruppel样因子5抗原
hz-1810hz LDH(Lactate Dehydrogenase)乳酸脱氢酶抗原
hz-0961hz Leptin receptor瘦素受体
hz-1451hz PAFAH2/Lp-PLA2/PLA2G7(platelet-activating factor acetylhydrolase 2)脂蛋白磷脂酶A2抗原
hz-1117hz Lgr5/GPR49肠上皮干细胞蛋白（多肽）
hz-0951hz LH(Luteinizing Hormone)促黄体生成素抗原
hz-0952hz LH(Luteinizing Hormone)人促黄体生成素(多肽)
hz-0984hz LH/CG Receptor(Luteinizing Hormone/Choriogonadotropin Receptor)人促黄体生成素受体抗原
hz-1054hz L-HDC (L-Histidine decarboxylase)L-组氨酸脱羧酶抗原
hz-1058hz LIF peptide白血病抑制因子抗原
hz-1458hz LIFR/CD118 peptide白血病抑制因子受体抗原
hz-1177hz Lingo-1Nogo受体作用蛋白抗原
hz-2035hz LIS1(Lissencephaly-1 protein)无脑回的致病基因LIS1抗原
hz-0824hz LFABP/FABP-1(Liver Fatty acid binding protein)肝脏型脂肪酸结合蛋白抗原
hz-0897hz LFABP/FABP-2(Liver Fatty acid binding protein)肝脏型脂肪酸结合蛋白抗原
hz-0821hz LN (laminin)层粘连蛋白(多肽抗原)
hz-1526hz Laminin Beta1 peptide层粘连蛋白β1抗原
hz-1839hz lamin A核纤层蛋白A抗原
hz-2044hz LOX-1/OLR1凝集素样氧化型低密度脂蛋白受体
hz-0976hz LPLUNC1人鼻咽癌癌基因多肽抗原
hz-1311hz LYVE-1(lymphalic vessel endotheilial hyaluronan receptor 1)淋巴管内皮透明质酸受体抗原
hz-0439hz ACE( ACE, testis-specific isoform precursor)血管紧张素转换酶(抗原)
hz-2217hz Integrin alpha E2 peptide整合素alpha E2抗原
hz-1014hz Mac-1 (Mac-1/CR3/CD11b+CD18)巨噬细胞表面分子抗原
hz-0924hz Mafa(avian)(V-maf musculoaponeurotic fibrosarcoma oncogene homolog A)v-maf 肌腱膜纤维肉瘤癌基因同源物A抗原
hz-0817hz MAGE-1黑色素瘤相关
hz-1041hz MAPKK1 (MAP kinase kinase 1)丝裂原活化蛋白激酶激酶1抗原
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验and virus-infected cells is the release of perforin and granzyme proteins. Perforin proteins form pores in the membranes of the attacked cell, allowing the entry of Granzyme A and Granzyme B. Granzyme B induces caspase activation and cleavage of factors
Immunodetection of Granzyme B Tissue Distribution and Cellular Localisation
Investigation of Granzyme B (GrB) function and pathophysiology in both human settings and rodent models increasingly involve the use of indirect immunofluorescence imaging and fluorescence-activated cell sorting, which requires reliable GrB
Detection of Human and Mouse Granzyme B Activity in Cell Extracts
The serine protease granzyme B (GrB) is a key effector molecule in cell-mediated immunity, released by cytotoxic lymphocytes (CLs) to induce cell death in neoplastic or virus-infected cells. The ability to detect and measure GrB activity
技术资料暂无技术资料 索取技术资料
