Granzyme B ( GZMB )抗体

Granzyme B ( GZMB )抗体产品信息

免疫原 :
Recombinant human Granzyme B protein ( Catalog#10345-H08H )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human Granzyme B ( rhGranzyme B; Catalog#10345-H08H; NP_004122.1; Met 1- Tyr 247 ). Total IgG was purified by Protein A affinity chromatography.
Granzyme B ( GZMB )抗体Background
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of Granzyme B have been identified including the key substrate caspase-3, ICAD and Bid. Granzyme B is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.
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