CD48 / BCM1 抗体

CD48 / BCM1 抗体产品信息

免疫原 :
Recombinant human CD48 protein ( Catalog#10797-H08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human CD48 ( rh CD48; Catalog#10797-H08H; NP_001769.2; Met 1-Ser 220 ). Total IgG was purified by Protein A affinity chromatography.
CD48 / BCM1 抗体Background
CD48, also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. In rodents, CD48 is the ligand for CD2 whereas in humans, CD58 is the ligand for CD2. Human CD48 cDNA encodes a 243 aa precursor that includes a 26 aa signal sequence, a 194 aa mature protein that contains one Ig-like V-type domain and one Ig-like C2-type domain, and a 23 aa C-terminal propeptide. It has a high degree of sequence homology to CD58 (LFA-3), and human CD48 shares approximately 50% aa sequence identity with mouse and rat CD48. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.
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