FGFR4抗体

FGFR4抗体产品信息

免疫原 :
Human cell-derived rM FGFR4 extracellular domain ( Catalog # 50194-M08H )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse FGFR4 / FGF Receptor 4 extracellular domain ( rM FGFR4; Catalog#50194-M08H; Met 1- Asp 366; NP_032037.2 ). Total IgG was purified by Protein A affinity chromatography.
FGFR4抗体Background
Fibroblast growth factors (FGFs) and their receptors (FGFRs) influence a variety of physiological and pathological cellular processes, and different ligand/receptor pairs regulate cell growth in either a positive or negative manner depending on the cell type and stage of development. At least 22 distinct FGF ligands and 4 receptors (FGFR1–4) have been identified to date. Mouse FGFR4, also designated as protein-tyrosine kinase receptor MPK-11, is a member of FGFR subfamily of the tyrosine protein kinase superfamily. Mouse FGFR4 is originally isolated from fetal cerebellar RNA, and this type I transmembrane glycoprotein contains 3 C2-type Ig-like domains in the extracellular domain and a cytoplasmic tyrosine-kinase domain. The putative ligand for mouse FGFR4 is basic fibroblast growth factor, FGF6 and FGF19. Studies in FGFR4 null mice indicated that FGFR4 may be required for the development of skeletal muscle cell lineages, as well as effective muscle regeneration, and furthermore, it is also involved in cholesterol and bile acid metabolism and homeostasis.
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