PD1 / PDCD1 / CD279抗体

PD1 / PDCD1 / CD279抗体产品信息

免疫原 :
Recombinant mouse PDCD1 protein ( Catalog # 50124-M08H )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse ( rM PDCD1 ; Catalog # 50124-M08H ; Met 1- Gln 167 ; NP_032824.1 ). Total IgG was purified by Protein A affinity chromatography.
PD1 / PDCD1 / CD279抗体背景综述
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein composed of an IgV-type extracellular domain sharing 21–33% sequence identity with CTLA-4, CD28 and ICOS. PDCD1 belongs to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase and lacks the membrane-proximal cysteine residue required for homodimerization of other members of the CD28 family. PDCD1 was previously isolated from apoptosis-induced cells by subattractive hybridization. The deduced amino acid sequence of human PDCD1 was 60% identical to the mouse counterpart, and a putative tyrosine kinase-association motif was well conserved. Structural and biochemical analyses show that PDCD1 is monomeric in solution as well as on cell surface. The PDCD1 cytoplasmic domain has two tyrosine residues, the membrane-proximal one constitutes an immunoreceptor tyrosine-based inhibitory motif (ITIM) and the other an immunoreceptor tyrosine-based switch motif (ITSM). ITIM is widely found in immunoinhibitory receptors including CD72 and KIR, the membrane-proximal tyrosine residue may play a central role for the inhibitory function of PDCD1.
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